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Descriptor English: Gene Amplification
Descriptor Spanish: Amplificación de Genes
Descriptor amplificación génica
Entry term(s) amplificación de genes
Scope note: Incremento selectivo del número de copias de un gen que codifica una proteína específica sin un incremento proporcional de otros genes. Ocurre naturalmente mediante la escisión de una copia de secuencia de repetición de un cromosoma y su replicación extracromosómica en un plásmido, o mediante la producción de un transcripto de ARN de toda la secuencia de repetición del ARN ribosómico seguida por la transcripción inversa de la molécula para producir una copia adicional de la secuencia de ADN original. Se han introducido técnicas de laboratorio para inducir una replicación desproporcionada mediante entrecruzamiento desigual, captación de ADN de células lisadas, o generación de secuencias extracromosómicas derivadas de la replicación de círculo rodante.
Descriptor Portuguese: Amplificação de Genes
Descriptor French: Amplification de gène
Entry term(s): Amplification, Gene
Tree number(s): G05.308.250
G05.365.590.310
G05.558.315
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005784
Scope note: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
Annotation: for physiol process only; for technique use NUCLEIC ACID AMPLIFICATION TECHNIQUES or specifics
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Entry Combination: methods:Nucleic Acid Amplification Techniques
Previous Indexing: Genes (1966-1967)
Genes, Structural (1968-1979)
Nucleic Acid Hybridization (1971-1979)
Plasmids (1975-1979)
Public MeSH Note: 80
History Note: 80
Related: Gene Dosage MeSH
DeCS ID: 28047
Unique ID: D005784
NLM Classification: QU 475
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1980/01/01
Date of Entry: 1979/04/17
Revision Date: 2016/06/17
Gene Amplification - Preferred
Concept UI M0009060
Scope note A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
Preferred term Gene Amplification
Entry term(s) Amplification, Gene



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