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Descriptor English: beta 2-Microglobulin
Descriptor Spanish: Microglobulina beta-2
Descriptor microglobulina beta-2
Entry term(s) microglobulina-beta 2
timotaxina
Scope note: Proteína de 11 kDa asociada a la membrana externa de muchas células, incluidos los LINFOCITOS. Es la subunidad pequeña de las moléculas de clase I del MHC. Generalmente se requiere la asociación con la microglobulina beta-2 para el transporte de cadenas pesadas de clase I desde el retículo endoplásmico a la superficie celular. La microglobulina beta-2 está presente en pequeñas cantidades en el suero, el LÍQUIDO CEFALORRAQUÍDEO y la orina de las personas sanas y, en grado mucho mayor, en la orina y el plasma de los pacientes con PROTEINURIA tubular o insuficiencia renal y en receptores de trasplante de riñón.
Descriptor Portuguese: Microglobulina beta-2
Descriptor French: bêta-2-Microglobuline
Entry term(s): Thymotaxin
beta 2 Microglobulin
Tree number(s): D09.400.430.890.489.100
D12.776.124.790.223.100
D12.776.377.715.182.100
D12.776.395.550.489.100
D12.776.543.550.439.100
D23.050.301.500.100.175
D23.050.705.552.100.175
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001613
Scope note: An 11-kDa protein associated with the outer membrane of many cells including LYMPHOCYTES. It is the small subunit of MHC CLASS I MOLECULES. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, CEREBROSPINAL FLUID, and urine of healthy individuals, and to a much greater degree in the urine and plasma of patients with tubular PROTEINURIA, renal failure, or kidney transplants.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Beta Globulins (1973-1974)
Public MeSH Note: 1991; see BETA 2 MICROGLOBULIN 1984-1990; BETA 2-MICROGLOBULIN was indexed under BETA GLOBULINS 1975-1983
History Note: 1991 (1975); use BETA 2 MICROGLOBULIN 1984-1990
DeCS ID: 29233
Unique ID: D001613
NLM Classification: WH 400
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1984/01/01
Date of Entry: 1974/11/19
Revision Date: 2018/02/01
beta 2-Microglobulin - Preferred
Concept UI M0002412
Scope note An 11-kDa protein associated with the outer membrane of many cells including LYMPHOCYTES. It is the small subunit of MHC CLASS I MOLECULES. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, CEREBROSPINAL FLUID, and urine of healthy individuals, and to a much greater degree in the urine and plasma of patients with tubular PROTEINURIA, renal failure, or kidney transplants.
Preferred term beta 2-Microglobulin
Entry term(s) Thymotaxin
beta 2 Microglobulin



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