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Descriptor English: Hirudins
Descriptor Spanish: Hirudinas
Descriptor hirudinas
Entry term(s) hirudina
Scope note: Polipéptidos de cadena simple, de unos 65 aminoácidos (7 kDa), que se encuentra en las SANGUIJUELAS; tienen un extremo N hidrófobo neutro, un extremo C hidrófilo ácido y una región central hidrófoba compacta. Las hirudinas recombinantes sin sulfatación de tyr-63 se conocen como "hirudinas desulfatadas". Forman un complejo no covalente estable con la TROMBINA ALFA, con lo que se suprime su capacidad de fraccionar el FIBRONÓGENO.
Descriptor Portuguese: Hirudinas
Descriptor French: Hirudines
Entry term(s): Hirudin
Tree number(s): D12.644.861.060.875
D12.776.872.060.875
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D006629
Scope note: Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
UL ultrastructure
UR urine
Entry Combination: therapeutic use:Hirudin Therapy
Pharm Action: Antithrombins
Fibrinolytic Agents
Public MeSH Note: 2005; see HIRUDIN 1963-2004
History Note: 2005(1963)
DeCS ID: 29410
Unique ID: D006629
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2005/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/06/22
Hirudins - Preferred
Concept UI M0465835
Scope note Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
Preferred term Hirudins
Hirudin - Narrower
Concept UI M0010382
Scope note A 65-residue polypeptide from LEECHES.
Preferred term Hirudin



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