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Descriptor English: Heparin Cofactor II
Descriptor Spanish: Cofactor II de Heparina
Descriptor cofactor II de la heparina
Scope note: Proteína plasmática sulfatada con un PM de aproximadamente 66 kDa que se asemeja a la ANTITROMBINA III. La proteína es un inhibidor de la trombina en plasma y se activa por el dermatán sulfato o heparina. Es miembro de la superfamilia de las serpinas.
Descriptor Portuguese: Cofator II da Heparina
Descriptor French: Cofacteur II de l'héparine
Entry term(s): Heparin Co Factor II
Heparin Co-Factor II
Heparin Cofactor 2
Leuserpin 2
Protease Inhibitor Leuserpin 2
Serpin D1
Tree number(s): D12.644.861.060.750
D12.776.124.790.106.450
D12.776.377.715.085.450
D12.776.872.060.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015844
Scope note: A sulfated plasma protein with a MW of approximately 66kDa that resembles ANTITHROMBIN III. The protein is an inhibitor of thrombin in plasma and is activated by dermatan sulfate or heparin. It is a member of the serpin superfamily.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Antithrombins
Serine Proteinase Inhibitors
Registry Number: 81604-65-1
CAS Type 1 Name: Heparin cofactor II
Previous Indexing: Antithrombins (1966-1989)
Glycoproteins (1966-1989)
Public MeSH Note: 90
History Note: 90
DeCS ID: 24709
Unique ID: D015844
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2015/06/22
Heparin Cofactor II - Preferred
Concept UI M0024263
Scope note A sulfated plasma protein with a MW of approximately 66kDa that resembles ANTITHROMBIN III. The protein is an inhibitor of thrombin in plasma and is activated by dermatan sulfate or heparin. It is a member of the serpin superfamily.
Preferred term Heparin Cofactor II
Entry term(s) Heparin Co Factor II
Heparin Co-Factor II
Heparin Cofactor 2
Leuserpin 2
Protease Inhibitor Leuserpin 2
Serpin D1



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