DeCS

Descriptor English:

Trimetrexate

Descriptor Spanish:

Trimetrexato

Spanish from Spain

Descriptor	trimetrexato
Scope note:	Inhibidor no clásico del ácido fólico a través de la inhibición de la enzima dihidrofolato reductasa. Se está comprobando su eficacia como agente antineoplásico y como agente antiparasitario frente a la NEUMONIA POR PNEUMOCYSTIS en paciente con SIDA. La mielosupresión es el efecto tóxico limitante de la dosis.

Descriptor Portuguese:

Trimetrexato

Descriptor French:

Trimétrexate

Tree number(s):

D03.633.100.786.925

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D016597

Scope note:

A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Antifungal Agents
Antimetabolites, Antineoplastic
Folic Acid Antagonists

Registry Number:

UPN4ITI8T4

CAS Type 1 Name:

2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-

DeCS ID:

29766

Unique ID:

D016597

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents