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Descriptor English: Afatinib
Descriptor Spanish: Afatinib
Descriptor Portuguese: Afatinib
Descriptor French: Afatinib
Entry term(s): (2E)-N-(4-(3-Chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide
Afatinib Dimaleate
Afatinib Maleate
BIBW 2992
BIBW 2992 MA2
BIBW 2992MA2
BIBW-2992
BIBW-2992-MA2
BIBW-2992MA2
BIBW2992
BIBW2992 MA2
Gilotrif
Tree number(s): D02.065.132
D03.633.100.786.188
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077716
Scope note: A quinazoline and butenamide derivative that acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER.
Annotation:
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Protein Kinase Inhibitors
Registry Number: 41UD74L59M
CAS Type 1 Name: 2-Butenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydro-3-furanyl)oxy)-6-quinazolinyl)-4-(dimethylamino)-, (2E)-
Public MeSH Note: 2019; AFATINIB was indexed under QUINAZOLINES 2007-2018
History Note: 2019 (2007)
DeCS ID: 57729
Unique ID: D000077716
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/07/03
Afatinib - Preferred
Concept UI M0561143
Scope note A quinazoline and butenamide derivative that acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER.
Preferred term Afatinib
Entry term(s) (2E)-N-(4-(3-Chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide
BIBW-2992-MA2 - Narrower
Concept UI M000623446
Preferred term BIBW-2992-MA2
Entry term(s) BIBW 2992 MA2
BIBW 2992MA2
BIBW-2992MA2
BIBW2992 MA2
Afatinib Maleate - Narrower
Concept UI M000641345
Preferred term Afatinib Maleate
BIBW 2992 - Narrower
Concept UI M0513702
Preferred term BIBW 2992
Entry term(s) BIBW-2992
BIBW2992
Gilotrif - Narrower
Concept UI M000622964
Preferred term Gilotrif
Afatinib Dimaleate - Narrower
Concept UI M000623445
Preferred term Afatinib Dimaleate



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