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Descriptor English: Mice, SCID
Descriptor Spanish: Ratones SCID
Descriptor ratones SCID
Entry term(s) ratas SCID-hu
ratas inmunodeficientes combinadas graves
ratas inmunodeficientes combinadas severas
Scope note: Ratones homocigóticos para el gen recesivo autosómico mutante scid que se localiza en el extremo centromérico del cromosoma 16. Estos ratones no tienen linfocitos funcionales, maduros y, por tanto, son muy susceptibles a las infecciones oportunistas letales si no reciben tratamiento crónico con antibióticos. La ausencia de inmunidad celular-B y T recuerda al síndrome de inmunodeficiencia combinada severa (IDCS) en niños. Los ratones SCID son útiles como modelos animales ya que son receptivos a la implantación de un sistema inmune de humanos que produce ratones hematoquiméricos SCID-humanos (SCID-hu).
Descriptor Portuguese: Camundongos SCID
Descriptor French: Souris SCID
Entry term(s): Immunodeficient Mice, Severe Combined
Mice, SCID-hu
Mouse, SCID
Mouse, SCID hu
Mouse, SCID-hu
SCID Mice
SCID Mouse
SCID hu Mice
SCID-hu Mice
SCID-hu Mouse
Severe Combined Immunodeficient Mice
Tree number(s): B01.050.150.900.649.313.992.635.505.500.550.780
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016513
Scope note: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Annotation: NIM with no qualifiers when experimental animal
Allowable Qualifiers: AB abnormalities
AH anatomy & histology
BL blood
CF cerebrospinal fluid
CL classification
EM embryology
GD growth & development
GE genetics
IM immunology
IN injuries
ME metabolism
MI microbiology
PH physiology
PS parasitology
PX psychology
SU surgery
UR urine
VI virology
Previous Indexing: Mice, Mutant Strains (1983-1991)
Public MeSH Note: 92
History Note: 92
DeCS ID: 29970
Unique ID: D016513
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/01/03
Revision Date: 2017/07/11
Mice, SCID - Preferred
Concept UI M0025206
Scope note Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Preferred term Mice, SCID
Entry term(s) Immunodeficient Mice, Severe Combined
Mouse, SCID
SCID Mice
SCID Mouse
Severe Combined Immunodeficient Mice
Mouse, SCID-hu - Related but not broader or narrower
Concept UI M0025207
Preferred term Mouse, SCID-hu
Entry term(s) Mice, SCID-hu
Mouse, SCID hu
SCID hu Mice
SCID-hu Mice
SCID-hu Mouse



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