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Descriptor in English: Mice, Knockout
Descriptor in Spanish: Ratones Noqueados
Descriptor in Portuguese: Camundongos Knockout
Descriptor in French: Souris knockout
Entry term(s): Knock-out Mice
Knockout Mice
Knockout Mouse
Mice, Knock out
Mice, Knock-out
Mouse, Knockout
Tree number(s): B01.050.050.136.500.500
B01.050.150.900.649.313.992.635.505.500.550.455
B01.050.150.900.649.313.992.635.505.500.800.500
Scope note: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Annotation: NIM no qualif when exper animal; do not forget also to check MICE
Allowable Qualifiers: AB abnormalities
AH anatomy & histology
BL blood
CF cerebrospinal fluid
CL classification
EM embryology
GD growth & development
GE genetics
IM immunology
IN injuries
ME metabolism
MI microbiology
PH physiology
PS parasitology
PX psychology
SU surgery
UR urine
VI virology
History Note: 94
See also the descriptors: Gene Knockout Techniques MeSH
DeCS UI: 31308
Descriptor UI: D018345
Date Established: 1994/01/01
Date of Entry: 1993/06/03
Revision Date: 2017/07/11
Mice, Knockout - Preferred
Concept UI M0027579
Scope note Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Preferred term Mice, Knockout
Entry term(s) Knock-out Mice
Knockout Mice
Knockout Mouse
Mice, Knock out
Mice, Knock-out
Mouse, Knockout



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