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Descriptor English: Lupus Coagulation Inhibitor
Descriptor Spanish: Inhibidor de Coagulación del Lupus
Descriptor anticoagulante lúpico
Entry term(s) autoanticuerpo anticoagulante lúpico
autoanticuerpos anticoagulantes lúpicos
inhibidor lúpico de la coagulación
Scope note: Anticuerpo antifosfolipídico que se encuentra asociado a diversas enfermedades (por ejemplo, LUPUS ERITEMATOSO SISTÉMICO y SÍNDROME ANTIFOSFOLIPÍDICO) y también en personas sanas. In vitro, este anticuerpo interfiere en la conversión de protrombina a trombina y prolonga el tiempo de tromboplastina parcial. In vivo ejerce un efecto procoagulante que da lugar a trombosis especialmente en las venas y arterias principales. Causa además complicaciones obstétricas, incluida la muerte fetal y el aborto espontáneo, así como diversas complicaciones hematológicas y neurológicas.
Descriptor Portuguese: Inibidor de Coagulação do Lúpus
Descriptor French: Inhibiteur lupique de la coagulation
Entry term(s): Anticoagulant, Lupus
Coagulation Inhibitor, Lupus
Inhibitor, Lupus Coagulation
Lupus Anticoagulant
Lupus Anticoagulant Autoantibodies
Lupus Anticoagulant Autoantibody
Tree number(s): D12.776.124.486.485.114.323.210.600
D12.776.124.790.651.114.323.210.600
D12.776.377.715.548.114.323.210.600
D23.113.475
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016682
Scope note: An antiphospholipid antibody found in association with a variety of diseases (e.g., SYSTEMIC LUPUS ERYTHEMATOSUS and ANTIPHOSPHOLIPID SYNDROME) as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Autoantibodies (1966-1991)
Blood Coagulation Factors (1966-1991)
Public MeSH Note: 92; LUPUS COAGULATION INHIBITOR was indexed under BLOOD COAGULATION FACTORS/immunology 1986-91 & BLOOD COAGULATION FACTORS/antagonists & inhibitors 1978-88
Online Note: use LUPUS COAGULATION INHIBITOR (NM) to search LUPUS COAGULATION INHIBITOR 1980-91
History Note: 92; was LUPUS COAGULATION INHIBITOR (NM) 1978-91
Entry Version: LUPUS COAG INHIB
Related: Antiphospholipid Syndrome MeSH
DeCS ID: 30002
Unique ID: D016682
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/07/12
Revision Date: 2005/07/19
Lupus Coagulation Inhibitor - Preferred
Concept UI M0025416
Scope note An antiphospholipid antibody found in association with a variety of diseases (e.g., SYSTEMIC LUPUS ERYTHEMATOSUS and ANTIPHOSPHOLIPID SYNDROME) as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
Preferred term Lupus Coagulation Inhibitor
Entry term(s) Anticoagulant, Lupus
Coagulation Inhibitor, Lupus
Inhibitor, Lupus Coagulation
Lupus Anticoagulant
Lupus Anticoagulant Autoantibodies
Lupus Anticoagulant Autoantibody



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