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Descriptor English: Clonazepam
Descriptor Spanish: Clonazepam
Descriptor clonazepam
Entry term(s) 5-(2-clorofenil)-1,3-dihidro-7-nitro-2H-1,4-benzodiacepin-2-ona
Klonopin
Scope note: Anticonvulsivante utilizado para diversos tipos de ataques, incluidos los ataques miotónicos o atónicos, epilepsia fotosensible, y crisis de ausencia, aunque puede desarrollar tolerancia. Es poco efectivo en los ataques tónico-clónicos generalizados o parciales. El mecanismo de acción parece ser que está ralacionado con la magnificación de las respuestas de los receptores del ÁCIDO GAMMA-AMINOBUTÍRICO.
Descriptor Portuguese: Clonazepam
Descriptor French: Clonazépam
Entry term(s): 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-
Antelepsin
Klonopin
Rivotril
Ro 5-4023
Ro 54023
Tree number(s): D03.633.100.079.080.070.150
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002998
Scope note: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticonvulsants
GABA Modulators
Registry Number: 5PE9FDE8GB
CAS Type 1 Name: 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-
Previous Indexing: Benzodiazepinones (1974)
Chlorobenzenes (1974)
Nitro Compounds (1974)
Public MeSH Note: 87; was see under BENZODIAZEPINONES 1975-86
History Note: 87(75); was see under BENZODIAZEPINONES 1975-86
DeCS ID: 3023
Unique ID: D002998
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1974/11/11
Revision Date: 2020/02/06
Clonazepam - Preferred
Concept UI M0004601
Scope note An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
Preferred term Clonazepam
Entry term(s) 2H-1,4-Benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-
Ro 5-4023 - Narrower
Concept UI M0353442
Preferred term Ro 5-4023
Entry term(s) Ro 54023
Antelepsin - Narrower
Concept UI M0004602
Preferred term Antelepsin
Rivotril - Related but not broader or narrower
Concept UI M0004603
Preferred term Rivotril
Klonopin - Related but not broader or narrower
Concept UI M000675698
Preferred term Klonopin



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