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Descriptor English: Complement Factor H
Descriptor Spanish: Factor H de Complemento
Descriptor factor H del complemento
Entry term(s) factor H
Scope note: Importante regulador soluble de la vía alternativa de activación del complemento (VÍA ALTERNATIVA DE ACTIVACIÓN DEL COMPLEMENTO). Es una glicoproteína de 139 kDa que se expresa por el hígado y se segrega a la sangre. Se une al COMPLEMENTO C3B y hace que iC3b (complemento 3b inactivado) sea susceptible al desdoblamiento por el FACTOR I DEL COMPLEMENTO. El factor H del complemento inhibe también la asociación de C3b con el FACTOR B DEL COMPLEMENTO para formar la proenzima C3bB, y promueve la disociación de Bb del complejo C3bBb (CONVERTASA C3 DE LA VÍA ALTERNATIVA DEL COMPLEMENTO).
Descriptor Portuguese: Fator H do Complemento
Descriptor French: Facteur H du complément
Entry term(s): Factor H
Factor H, Complement
Tree number(s): D12.776.124.486.274.920.325.200
D12.776.124.790.223.200
D12.776.377.715.182.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017242
Scope note: An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Complement Inactivating Agents
Registry Number: 80295-65-4
CAS Type 1 Name: Complement factor H
Previous Indexing: Beta Globulins (1978-1979)
Complement 3b Inactivators (1980-1992)
Glycoproteins (1978-1979)
Public MeSH Note: 93; COMPLEMENT FACTOR H was indexed under COMPLEMENT 3B INACTIVATORS 1980-92 & under BETA GLOBULINS and GLYCOPROTEINS 1978-79
Online Note: use COMPLEMENT FACTOR H (NM) to search COMPLEMENT FACTOR H 1978-92
History Note: 93; was COMPLEMENT FACTOR H (NM) 1978-92
DeCS ID: 30775
Unique ID: D017242
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1993/01/01
Date of Entry: 1992/05/07
Revision Date: 2005/07/07
Complement Factor H - Preferred
Concept UI M0026162
Scope note An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).
Preferred term Complement Factor H
Entry term(s) Factor H
Factor H, Complement



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