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Descriptor English: Phosphofructokinase-1
Descriptor Spanish: Fosfofructoquinasa-1
Descriptor fosfofructocinasa-1
Entry term(s) 6-fosfofructocinasa
6-fosfofructoquinasa
fosfofructoquinasa-1
Scope note: Enzima alostérica que regula la glucólisis, catalizando la transferencia de un grupo fosfato del ATP a la fructosa-6-fosfato para producir fructosa-1,6-bifosfato. También son aceptores la D-tagatosa-6-fosfato y la sedoheptulosa-7-fosfato. Son donadores la UTP, CTP e ITP. En la fosfofructoquinasa-1 humana se han identificado tres tipos de subunidades: FOSFOFRUCTOQUINASA-1 TIPO MUSCULAR, FOSFOFRUCTOQUINASA-1 TIPO HEPÁTICO y FOSFOFRUCTOQUINASA-1 TIPO C, encontradas en las plaquetas, el cerebro y otros tejidos.
Descriptor Portuguese: Fosfofrutoquinase-1
Descriptor French: Phosphofructokinase-1
Entry term(s): 6 Phosphofructokinase
6-Phosphofructo-1-kinase
6-Phosphofructokinase
Fructose-6-P 1-Kinase
Fructose-6-phosphate 1-Phosphotransferase
Phosphofructokinase 1
Tree number(s): D08.811.913.696.620.225.850.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010732
Scope note: An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.
Annotation: general or unspecified; prefer specifics
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.1.11
CAS Type 1 Name: ATP:D-fructose-6-phosphate 1-phosphotransferase
Public MeSH Note: 2002; see 6-PHOSPHOFRUCTOKINASE 1993-2001, see PHOSPHOFRUCTOKINASE 1965-1992
History Note: 2002
Related: Glycogen Storage Disease Type VII MeSH
Phosphofructokinase-2 MeSH
DeCS ID: 30875
Unique ID: D010732
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2009/07/13
Phosphofructokinase-1 - Preferred
Concept UI M0016667
Scope note An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. D-tagatose- 6-phosphate and sedoheptulose-7-phosphate also are acceptors. UTP, CTP, and ITP also are donors. In human phosphofructokinase-1, three types of subunits have been identified. They are PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE; PHOSPHOFRUCTOKINASE-1, LIVER TYPE; and PHOSPHOFRUCTOKINASE-1, TYPE C; found in platelets, brain, and other tissues.
Preferred term Phosphofructokinase-1
Entry term(s) 6 Phosphofructokinase
6-Phosphofructo-1-kinase
6-Phosphofructokinase
Fructose-6-P 1-Kinase
Fructose-6-phosphate 1-Phosphotransferase
Phosphofructokinase 1



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