| Descriptor English: | B7-1 Antigen | ||||||
| Descriptor Spanish: |
Antígeno B7-1
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| Descriptor Portuguese: | Antígeno B7-1 | ||||||
| Descriptor French: | Antigène CD80 | ||||||
| Entry term(s): |
Antigen, B7 1 Antigen, B7-1 Antigens, CD80 B Cell Activation Antigen B-Cell Activation Antigen B7 1 Antigen B7 1 Costimulatory Molecule B7 1 Ligand B7-1 Costimulatory Molecule B7-1 Ligand CD80 Antigen CD80 Antigens Costimulatory Molecule, B7-1 Ligand, B7-1 |
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| Tree number(s): |
D12.776.467.150.100 D12.776.543.095.100 D23.050.301.285.100 D23.529.168.100 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D018122 | ||||||
| Scope note: | A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Antigens, Surface (1991-1993) |
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| Public MeSH Note: | 2018; see ANTIGENS, CD80 1996-2017; see B-CELL ACTIVATION ANTIGEN 1994-95; B7-1 ANTIGEN was indexed under B-CELL ACTIVATION ANTIGEN 1994-95; B CELL ACTIVATION ANTIGEN B7 was indexed under ANTIGENS, SURFACE 1991-93 |
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| History Note: | 2018 (1991) |
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| DeCS ID: | 31626 | ||||||
| Unique ID: | D018122 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1994/01/01 | ||||||
| Date of Entry: | 1993/06/04 | ||||||
| Revision Date: | 2017/05/24 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors -
CHEMICALS AND DRUGS
Biological Factors [D23]Biological Factors
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B7-1 Antigen
- Preferred
| Concept UI |
M0027327 |
| Scope note | A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE. |
| Preferred term | B7-1 Antigen |
| Entry term(s) |
Antigen, B7 1 Antigen, B7-1 Antigens, CD80 B Cell Activation Antigen B-Cell Activation Antigen B7 1 Antigen B7 1 Costimulatory Molecule B7 1 Ligand B7-1 Costimulatory Molecule B7-1 Ligand CD80 Antigen CD80 Antigens Costimulatory Molecule, B7-1 Ligand, B7-1 |
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