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Descriptor English: V-Set Domain-Containing T-Cell Activation Inhibitor 1
Descriptor Spanish: Inhibidor 1 de la Activación de Células T con Dominio V-Set
Descriptor inhibidor 1 de la activación de células T con dominios V-set
Entry term(s) inhibidor 1 de la activación de linfocitos T con dominios V-set
Scope note: Subtipo de antígeno B7 que inhibe la coestimulación de la activación y proliferación de los linfocitos T, producción de citoquinas y desarrollo de citotoxicidad. La sobreexpresión de esta proteína en una variedad de células tumorales sugiere su rol en la EVASIÓN INMUNITARIA DEL TUMOR.
Descriptor Portuguese: Inibidor 1 da Ativação de Células T com Domínio V-Set
Descriptor French: V-set domain-containing T-cell activation inhibitor 1
Entry term(s): B7H4 Immune Costimulatory Protein
Immune Costimulatory Protein B7 H4
Immune Costimulatory Protein B7-H4
T Cell Costimulatory Molecule B7x
T-Cell Costimulatory Molecule B7x
V Set Domain Containing T Cell Activation Inhibitor 1
Tree number(s): D12.776.467.150.900
D12.776.543.095.900
D23.050.301.285.900
D23.529.168.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D060907
Scope note: A B7 antigen subtype that inhibits the costimulation of T-cell activation, proliferation, cytokine production and development of cytotoxicity. The over expression of this protein in a variety of tumor cell types suggests its role in TUMOR IMMUNE EVASION.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Antigens, CD80 (2003-2011)
Public MeSH Note: 2012
History Note: 2012
Related: Immunoglobulin Domains MeSH
DeCS ID: 54626
Unique ID: D060907
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2012/01/01
Date of Entry: 2011/07/01
Revision Date: 2017/05/24
V-Set Domain-Containing T-Cell Activation Inhibitor 1 - Preferred
Concept UI M0555798
Scope note A B7 antigen subtype that inhibits the costimulation of T-cell activation, proliferation, cytokine production and development of cytotoxicity. The over expression of this protein in a variety of tumor cell types suggests its role in TUMOR IMMUNE EVASION.
Preferred term V-Set Domain-Containing T-Cell Activation Inhibitor 1
Entry term(s) B7H4 Immune Costimulatory Protein
Immune Costimulatory Protein B7 H4
Immune Costimulatory Protein B7-H4
T Cell Costimulatory Molecule B7x
T-Cell Costimulatory Molecule B7x
V Set Domain Containing T Cell Activation Inhibitor 1



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