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Descriptor English: Antibodies, Bispecific
Descriptor Spanish: Anticuerpos Biespecíficos
Descriptor anticuerpos biespecíficos
Entry term(s) anticuerpos bifuncionales
Scope note: Anticuerpos, con frecuencia monoclonales, en los que los dos sitios de unión a antígenos son específicos en relación con DETERMINANTES ANTIGÉNICOS. Son anticuerpos artificiales producidos por enlaces químicos cruzados, fusión de células de HIBRIDOMA o por técnicas genéticas moleculares. Funcionan como principales mediadores de la citotoxicidad celular seleccionada como objetivo y se ha demostrado que son eficientes en la selección como objetivos de medicamentos, toxinas, haptenos radioetiquetados y células efectoras frente a tejido enfermo, principalmente tumores.
Descriptor Portuguese: Anticorpos Biespecíficos
Descriptor French: Anticorps bispécifiques
Entry term(s): Antibodies, Bifunctional
Antibodies, Bispecific Monoclonal
Bifunctional Antibodies
Bispecific Antibodies
Bispecific Monoclonal Antibodies
Monoclonal Antibodies, Bispecific
Tree number(s): D12.776.124.486.485.114.125
D12.776.124.790.651.114.134
D12.776.377.715.548.114.134
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018033
Scope note: Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
Annotation: do not coordinate with ANTIBODY FORMATION for /biosynthesis
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Antibodies (1985-1993)
specific Antibodies (1985-1993)
Public MeSH Note: 94
History Note: 94
Related: Immunotoxins MeSH
Radioimmunotherapy MeSH
DeCS ID: 31649
Unique ID: D018033
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/06/04
Revision Date: 2010/06/25
Antibodies, Bispecific - Preferred
Concept UI M0027219
Scope note Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
Preferred term Antibodies, Bispecific
Entry term(s) Antibodies, Bifunctional
Bifunctional Antibodies
Bispecific Antibodies
Bispecific Monoclonal Antibodies - Narrower
Concept UI M0027218
Preferred term Bispecific Monoclonal Antibodies
Entry term(s) Antibodies, Bispecific Monoclonal
Monoclonal Antibodies, Bispecific



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