DeCS

Descriptor English:

ATP Binding Cassette Transporter, Subfamily B, Member 1

Descriptor Spanish:

Miembro 1 de la Subfamilia B de Casetes de Unión a ATP

Spanish from Spain

Descriptor	transportador de casetes de unión al ATP, subfamilia B, miembro 1
Entry term(s)	P-glicoproteína antígeno 243 casete de unión a ATP, subfamilia B, miembro 1 glicoproteína P glicoproteína-P proteína 1 de resistencia multimedicamentosa proteína ABCB1 proteína MDR1 proteína PGY 1 proteína PGY-1 transportador 1, casete de unión a ATP, subfamilia B
Scope note:	Glicoproteína transmembranaria de 170 kDa de la familia de los TRANSPORTADORES DE CASETES DE UNIÓN A ATP. Hace las veces de bomba de achique dependiente de ATP en relación con una variedad de compuestos químicos, como son muchos ANTINEOPLÁSICOS. La excesiva expresión de esta glucoproteína se asocia con resistencia multimedicamentosa ( ver RESISTENCIA MEDICAMENTOSA MÚLTIPLE).

Descriptor Portuguese:

Membro 1 da Subfamília B de Cassetes de Ligação de ATP

Descriptor French:

Glycoprotéine P

Entry term(s):

ABCB1 Protein
ATP Binding Cassette Transporter, Sub-Family B, Member 1
ATP-Binding Cassette, Sub-Family B, Member 1
Antigen, CD243
CD243 Antigen
MDR1 Protein
Multidrug Resistance Protein 1
P Glycoprotein
P-Glycoprotein
PGY 1 Protein
PGY-1 Protein

Tree number(s):

D12.776.157.530.100.075.063
D12.776.157.530.450.074.500.500.250.125
D12.776.395.550.020.400.153
D12.776.543.550.192.400.153
D12.776.543.585.100.200.125
D12.776.543.585.450.074.500.500.250.125

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D020168

Scope note:

A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).

Annotation:

note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B is also available

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Previous Indexing:

P-Glycoprotein (1995-1998)

Public MeSH Note:

2019; see ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1 2018; see P-GLYCOPROTEIN 1995-2017; ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B, MEMBER 1 was indexed under P-GLYCOPROTEIN 1995-1998; under CARRIER PROTEINS & MEMBRANE GLYCOPROTEINS 1980-1994; under GLYCOPROTEINS 1980-1987; and under MEMBRANE PROTEINS 1980-1982

Concept UI	M0029890
Scope note	A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Preferred term	ATP Binding Cassette Transporter, Subfamily B, Member 1
Entry term(s)	ABCB1 Protein ATP Binding Cassette Transporter, Sub-Family B, Member 1 ATP-Binding Cassette, Sub-Family B, Member 1 Antigen, CD243 CD243 Antigen MDR1 Protein Multidrug Resistance Protein 1 P Glycoprotein P-Glycoprotein PGY 1 Protein PGY-1 Protein

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