DeCS

Descriptor English:

ATP Binding Cassette Transporter, Subfamily B

Descriptor Spanish:

Subfamilia B de Transportador de Casetes de Unión a ATP

Spanish from Spain

Descriptor	transportadores de casetes de unión al ATP, subfamilia B
Entry term(s)	P-glicoproteínas glicoproteínas P glicoproteínas-P proteínas de la subfamilia B de casetes de unión al ATP proteínas de resistencia multimedicamentosa
Scope note:	Subfamilia de proteínas transmembranarias de la superfamilia de TRANSPORTADORES DE CASETES DE UNIÓN A ATP estrechamente relacionadas en sus secuencias con el TRANSPORTADOR DE CASETES DE UNIÓN AL ATP, SUBFAMILIA B, MIEMBRO 1. Cuando se sobreexpresan funcionan como bombas de salida dependientes de ATP capaces de expulsar fármacos lipófilos (especialmente ANTINEOPLÁSICOS) de las células, lo que causa resistencia multimedicamentosa (RESISTENCIA A MÚLTIPLES MEDICAMENTOS). Aunque el TRANSPORTADOR DE CASETES DE UNIÓN AL ATP, SUBFAMILIA B, comparte similitudes funcionales con las PROTEÍNAS ASOCIADAS A RESISTENCIA A MÚLTIPLES MEDICAMENTOS, son dos subclases distintas de los TRANSPORTADORES DE CASETES DE UNIÓN A ATP y tienen una escasa homología de secuencias.

Descriptor Portuguese:

Subfamília B de Transportador de Cassetes de Ligação de ATP

Descriptor French:

Sous-famille B de transporteurs à cassette liant l'ATP

Entry term(s):

ATP Binding Cassette Transporter, Sub Family B
ATP Binding Cassette Transporter, Sub-Family B
ATP Binding Cassette, Sub Family B Proteins
ATP-Binding Cassette, Sub-Family B Proteins
Multidrug Resistance Proteins
P Glycoproteins
P-Glycoproteins

Tree number(s):

D09.400.430.890.020.400
D12.776.157.530.100.075
D12.776.157.530.450.074.500.500.250
D12.776.395.550.020.400
D12.776.543.550.192.400
D12.776.543.585.100.200
D12.776.543.585.450.074.500.500.250

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D018435

Scope note:

A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.

Annotation:

note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 is also available

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Previous Indexing:

Glycoproteins (1980-1987)
Membrane Glycoproteins (1989-1994)
Membrane Proteins (1980-1988)

Public MeSH Note:

2019; see ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B 2018; see P-GLYCOPROTEIN 1995-1998; P-GLYCOPROTEIN was indexed under CARRIER PROTEINS & MEMBRANE GLYCOPROTEINS 1980-1994, GLYCOPROTEINS 1980-1987, and MEMBRANE PROTEINS 1980-1982

Concept UI	M0027659
Scope note	A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
Preferred term	ATP Binding Cassette Transporter, Subfamily B
Entry term(s)	ATP Binding Cassette Transporter, Sub Family B ATP Binding Cassette Transporter, Sub-Family B ATP Binding Cassette, Sub Family B Proteins ATP-Binding Cassette, Sub-Family B Proteins Multidrug Resistance Proteins P Glycoproteins P-Glycoproteins

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