| Descriptor English: | ATP Binding Cassette Transporter, Subfamily B | ||||||
| Descriptor Spanish: |
Subfamilia B de Transportador de Casetes de Unión a ATP
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| Descriptor Portuguese: | Subfamília B de Transportador de Cassetes de Ligação de ATP | ||||||
| Descriptor French: | Sous-famille B de transporteurs à cassette liant l'ATP | ||||||
| Entry term(s): |
ATP Binding Cassette Transporter, Sub Family B ATP Binding Cassette Transporter, Sub-Family B ATP Binding Cassette, Sub Family B Proteins ATP-Binding Cassette, Sub-Family B Proteins Multidrug Resistance Proteins P Glycoproteins P-Glycoproteins |
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| Tree number(s): |
D12.776.157.530.100.075 D12.776.157.530.450.074.500.500.250 D12.776.395.550.020.400 D12.776.543.550.192.400 D12.776.543.585.100.200 D12.776.543.585.450.074.500.500.250 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D018435 | ||||||
| Scope note: | A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. |
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| Annotation: | note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 is also available |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Glycoproteins (1980-1987) Membrane Glycoproteins (1989-1994) Membrane Proteins (1980-1988) |
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| Public MeSH Note: | 2019; see ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B 2018; see P-GLYCOPROTEIN 1995-1998; P-GLYCOPROTEIN was indexed under CARRIER PROTEINS & MEMBRANE GLYCOPROTEINS 1980-1994, GLYCOPROTEINS 1980-1987, and MEMBRANE PROTEINS 1980-1982 |
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| History Note: | 2019 (1999); use P-GLYCOPROTEIN 1995-1998 |
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| Related: |
Drug Resistance, Multiple
MeSH Genes, MDR MeSH Multidrug Resistance-Associated Proteins MeSH Rhodamine 123 MeSH | ||||||
| DeCS ID: | 33637 | ||||||
| Unique ID: | D018435 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1995/01/01 | ||||||
| Date of Entry: | 1994/01/25 | ||||||
| Revision Date: | 2019/04/29 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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ATP Binding Cassette Transporter, Subfamily B
- Preferred
| Concept UI |
M0027659 |
| Scope note | A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. |
| Preferred term | ATP Binding Cassette Transporter, Subfamily B |
| Entry term(s) |
ATP Binding Cassette Transporter, Sub Family B ATP Binding Cassette Transporter, Sub-Family B ATP Binding Cassette, Sub Family B Proteins ATP-Binding Cassette, Sub-Family B Proteins Multidrug Resistance Proteins P Glycoproteins P-Glycoproteins |
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