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Descriptor English: Aphasia, Primary Progressive
Descriptor Spanish: Afasia Progresiva Primaria
Descriptor afasia primaria progresiva
Entry term(s) afasia progresiva primaria
síndrome de Mesulam
Scope note: Forma progresiva de demencia caracterizada por pérdida global de las capacidades del lenguaje con preservación inicial de otras funciones cognitivas. Se han descrito subtipos con y sin fluidez. A la larga surge un patrón de disfunción cognitiva global, similar a la ENFERMEDAD DE ALZHEIMER. Anatomopatológicamente no hay cambios similares a los de la enfermedad de Alzheimer o de la ENFERMEDAD DE PICK. Sin embargo, se presentan cambios espongiformes en las capas corticales II y III del LÓBULO TEMPORAL y del LÓBULO FRONTAL. (Brain 1998 Jan;121(Pt 1):115-26)
Descriptor Portuguese: Afasia Primária Progressiva
Descriptor French: Aphasie progressive primaire
Entry term(s): Aphasias, Primary Progressive
Mesulam Syndrome
Mesulam's Syndrome
Primary Progressive Aphasia
Primary Progressive Aphasias
Progressive Aphasia, Primary
Progressive Aphasias, Primary
Syndrome, Mesulam
Syndrome, Mesulam's
Tree number(s): C10.228.140.380.132
C10.597.606.150.500.800.100.155
C23.888.592.604.150.500.800.100.155
F03.615.400.125
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018888
Scope note: A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)
Annotation: a clinical entity: do not confuse with descriptions of the progression of aphasia in case reports
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
SU surgery
TH therapy
UR urine
VI virology
Previous Indexing: Aphasia (1982-1995)
Public MeSH Note: 1996
History Note: 1996
DeCS ID: 32833
Unique ID: D018888
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1994/12/27
Revision Date: 2015/06/30
Aphasia, Primary Progressive - Preferred
Concept UI M0028247
Scope note A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)
Preferred term Aphasia, Primary Progressive
Entry term(s) Aphasias, Primary Progressive
Mesulam Syndrome
Mesulam's Syndrome
Primary Progressive Aphasia
Primary Progressive Aphasias
Progressive Aphasia, Primary
Progressive Aphasias, Primary
Syndrome, Mesulam
Syndrome, Mesulam's



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