| Descriptor English: | Tissue Inhibitor of Metalloproteinases | ||||||
| Descriptor Spanish: |
Inhibidores Tisulares de Metaloproteinasas
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| Descriptor Portuguese: | Inibidores Teciduais de Metaloproteinases | ||||||
| Descriptor French: | Inhibiteur tissulaire des métalloprotéinases | ||||||
| Entry term(s): |
Metalloproteinase Tissue Inhibitor Metalloproteinases Tissue Inhibitor Proteins, TIMP TIMP Proteins Tissue Inhibitor of Metalloproteinase |
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| Tree number(s): |
D12.776.815.875 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019714 | ||||||
| Scope note: | A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes. |
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| Annotation: | general or unspecified; prefer specifics |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Matrix Metalloproteinase Inhibitors |
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| Previous Indexing: |
Enzyme Inhibitors (1989-1997) Glycoproteins (1980-1990) |
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| Public MeSH Note: | 98; COLLAGENASE INHIBITOR (now TISSUE INHIBITOR OF METALLOPROTEINASES) was indexed under GLYCOPROTEINS 1989-97 & ENZYME INHIBITORS 1980-90 |
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| History Note: | 98; see TISSUE INHIBITOR OF METALLOPROTEINASES (NM) 1980-97 |
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| Entry Version: | TISSUE INHIB METALLOPROTEINASES |
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| DeCS ID: | 33425 | ||||||
| Unique ID: | D019714 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1998/01/01 | ||||||
| Date of Entry: | 1997/06/20 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Tissue Inhibitor of Metalloproteinases
- Preferred
| Concept UI |
M0029270 |
| Scope note | A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes. |
| Preferred term | Tissue Inhibitor of Metalloproteinases |
| Entry term(s) |
Metalloproteinase Tissue Inhibitor Metalloproteinases Tissue Inhibitor Proteins, TIMP TIMP Proteins Tissue Inhibitor of Metalloproteinase |
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