Search
Descriptor English: Tissue Inhibitor of Metalloproteinase-2
Descriptor Spanish: Inhibidor Tisular de Metaloproteinasa-2
Descriptor inhibidor tisular de la metaloproteinasa 2
Entry term(s) TIMP-2
Scope note: Miembro de la familia de INHIBIDORES TISULARES DE LAS METALOPROTEINASAS. Es una proteína no glucosilada de 21 kDa, que se encuentra en los fluidos tisulares y es secretada por los fibroblastos humanos como un complejo con la progelatinasa A, y sin formar complejos por los macrófagos alveolares. Se ha demostrado que una sobreexpresión de TIMP-2 inhibe la actividad invasiva y metastásica de las células tumorales y disminuye el crecimiento tumoral in vivo.
Descriptor Portuguese: Inibidor Tecidual de Metaloproteinase-2
Descriptor French: Inhibiteur tissulaire de métalloprotéinase-2
Entry term(s): Metalloproteinase-2 Tissue Inhibitor
TIMP-2
Tissue Inhibitor of Metalloproteinase 2
Tree number(s): D12.776.815.875.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019716
Scope note: A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Matrix Metalloproteinase Inhibitors
Registry Number: 127497-59-0
Previous Indexing: Neoplasm Proteins (1989-1993)
Proteins (1990-1997)
Public MeSH Note: 1998; TISSUE INHIBITOR OF METALLOPROTEINASE 2 was indexed under PROTEINS 1990-97 & NEOPLASM PROTEINS 1989-1993
History Note: 1998; see TISSUE INHIBITOR OF METALLOPROTEINASE-2 (NM) 1989-1997
Entry Version: TISSUE INHIB METALLOPROTEINASE 2
DeCS ID: 33427
Unique ID: D019716
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/30
Revision Date: 2012/07/03
Tissue Inhibitor of Metalloproteinase-2 - Preferred
Concept UI M0029272
Scope note A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
Preferred term Tissue Inhibitor of Metalloproteinase-2
Entry term(s) Metalloproteinase-2 Tissue Inhibitor
TIMP-2
Tissue Inhibitor of Metalloproteinase 2



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey