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Descriptor English: Amino Acid Substitution
Descriptor Spanish: Sustitución de Aminoácidos
Descriptor sustitución de aminoácidos
Scope note: La sustitución que se produce de modo natural o inducido experimentalmente de uno o más AMINOÁCIDOS en una proteína con otra. Si se sustituye un aminoácido equivalente funcional, la proteína puede mantener la actividad de tipo salvaje. La sustitución también puede disminuir, aumentar, o eliminar la función de la proteína. Se utiliza con frecuencia la sustitución inducida experimentalmente para estudiar las actividades y enlaces de las enzimas.
Descriptor Portuguese: Substituição de Aminoácidos
Descriptor French: Substitution d'acide aminé
Entry term(s): Amino Acid Substitutions
Substitution, Amino Acid
Substitutions, Amino Acid
Tree number(s): E05.393.420.601.035
G05.558.109
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019943
Scope note: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Amino Acid Sequence (1966-1997)
Public MeSH Note: 98
History Note: 98
Related: Mutagenesis, Site-Directed MeSH
Mutation, Missense MeSH
DeCS ID: 33590
Unique ID: D019943
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2016/01/15
Amino Acid Substitution - Preferred
Concept UI M0029617
Scope note The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Preferred term Amino Acid Substitution
Entry term(s) Amino Acid Substitutions
Substitution, Amino Acid
Substitutions, Amino Acid



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