| Descriptor English: | Caspase 1 | ||||||
| Descriptor Spanish: |
Caspasa 1
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| Descriptor Portuguese: | Caspase 1 | ||||||
| Descriptor French: | Caspase-1 | ||||||
| Entry term(s): |
CASP1 Caspase Caspase, CASP1 Convertase, IL-1 beta Converting Enzyme, Interleukin-1 Converting Enzyme, Interleukin-1beta ICE Protease IL 1 beta Convertase IL 1 beta Converting Enzyme IL-1 beta Convertase IL-1 beta-Converting Enzyme IL1BC Enzyme Interleukin 1 Converting Enzyme Interleukin 1beta Converting Enzyme Interleukin-1 Converting Enzyme Interleukin-1beta Converting Enzyme Pro Caspase 1 Pro-Caspase-1 Procaspase 1 Procaspase-1 beta Convertase, IL-1 beta-Converting Enzyme, IL-1 |
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| Tree number(s): |
D08.811.277.656.262.500.126.550.100 D08.811.277.656.300.200.126.550.100 D12.776.476.075.405.550.100 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D020170 | ||||||
| Scope note: | A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Entry Combination: |
antagonists & inhibitors:Caspase Inhibitors
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| Registry Number: | EC 3.4.22.36 | ||||||
| Previous Indexing: |
Cysteine Proteinases (1995-1998) Metalloproteinases (1989-1994) |
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| Public MeSH Note: | 99; INTERLEUKIN 1BETA CONVERTING ENZYME (now CASPASE 1) was indexed under CYSTEINE PROTEINASES 1995-98 & METALLOPROTEINASES 1989-94 |
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| History Note: | 99; use CASPASE 1 (NM) 1989-98 |
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| Related: |
Apoptosis
MeSH Interleukin-1 MeSH | ||||||
| DeCS ID: | 33827 | ||||||
| Unique ID: | D020170 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1999/01/01 | ||||||
| Date of Entry: | 1998/06/10 | ||||||
| Revision Date: | 2015/11/23 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Caspase 1
- Preferred
Procaspase-1
- Narrower
| Concept UI |
M0029892 |
| Scope note | A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE. |
| Preferred term | Caspase 1 |
| Entry term(s) |
CASP1 Caspase Caspase, CASP1 Convertase, IL-1 beta Converting Enzyme, Interleukin-1 Converting Enzyme, Interleukin-1beta ICE Protease IL 1 beta Convertase IL 1 beta Converting Enzyme IL-1 beta Convertase IL-1 beta-Converting Enzyme IL1BC Enzyme Interleukin 1 Converting Enzyme Interleukin 1beta Converting Enzyme Interleukin-1 Converting Enzyme Interleukin-1beta Converting Enzyme beta Convertase, IL-1 beta-Converting Enzyme, IL-1 |
| Concept UI |
M0295647 |
| Preferred term | Procaspase-1 |
| Entry term(s) |
Pro Caspase 1 Pro-Caspase-1 Procaspase 1 |
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