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Descriptor English: Caspase 1
Descriptor Spanish: Caspasa 1
Descriptor caspasa 1
Entry term(s) CASP1
enzima convertidora de la IL-1 beta
enzima convertidora de la interleucina 1 beta
procaspasa 1
proteasa ICE
Scope note: Caspasa de prodominio largo con especificidad por la forma precursora de la INTERLEUCINA 1 BETA. Interviene en la INFLAMACIÓN convirtiendo catalíticamente las formas inactivas de las CITOCINAS, como la interleucina 1 beta, en su forma activa segregada. La caspasa 1 se denomina también enzima convertidora de la interleucina 1 beta y con frecuencia se abrevia como ICE.
Descriptor Portuguese: Caspase 1
Descriptor French: Caspase-1
Entry term(s): CASP1 Caspase
Caspase, CASP1
Convertase, IL-1 beta
Converting Enzyme, Interleukin-1
Converting Enzyme, Interleukin-1beta
ICE Protease
IL 1 beta Convertase
IL 1 beta Converting Enzyme
IL-1 beta Convertase
IL-1 beta-Converting Enzyme
IL1BC Enzyme
Interleukin 1 Converting Enzyme
Interleukin 1beta Converting Enzyme
Interleukin-1 Converting Enzyme
Interleukin-1beta Converting Enzyme
Pro Caspase 1
Pro-Caspase-1
Procaspase 1
Procaspase-1
beta Convertase, IL-1
beta-Converting Enzyme, IL-1
Tree number(s): D08.811.277.656.262.500.126.550.100
D08.811.277.656.300.200.126.550.100
D12.776.476.075.405.550.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020170
Scope note: A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Caspase Inhibitors
Registry Number: EC 3.4.22.36
Previous Indexing: Cysteine Proteinases (1995-1998)
Metalloproteinases (1989-1994)
Public MeSH Note: 99; INTERLEUKIN 1BETA CONVERTING ENZYME (now CASPASE 1) was indexed under CYSTEINE PROTEINASES 1995-98 & METALLOPROTEINASES 1989-94
History Note: 99; use CASPASE 1 (NM) 1989-98
Related: Apoptosis MeSH
Interleukin-1 MeSH
DeCS ID: 33827
Unique ID: D020170
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1999/01/01
Date of Entry: 1998/06/10
Revision Date: 2015/11/23
Caspase 1 - Preferred
Concept UI M0029892
Scope note A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
Preferred term Caspase 1
Entry term(s) CASP1 Caspase
Caspase, CASP1
Convertase, IL-1 beta
Converting Enzyme, Interleukin-1
Converting Enzyme, Interleukin-1beta
ICE Protease
IL 1 beta Convertase
IL 1 beta Converting Enzyme
IL-1 beta Convertase
IL-1 beta-Converting Enzyme
IL1BC Enzyme
Interleukin 1 Converting Enzyme
Interleukin 1beta Converting Enzyme
Interleukin-1 Converting Enzyme
Interleukin-1beta Converting Enzyme
beta Convertase, IL-1
beta-Converting Enzyme, IL-1
Procaspase-1 - Narrower
Concept UI M0295647
Preferred term Procaspase-1
Entry term(s) Pro Caspase 1
Pro-Caspase-1
Procaspase 1



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