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Descriptor English: Caspase 10
Descriptor Spanish: Caspasa 10
Descriptor caspasa 10
Entry term(s) CASP10
Mch4
proteasa apoptósica Mch4
Scope note: Caspasa con un largo prodiminio que contiene un dominio efector de muerte en su región prodominio. La activación de esta enzima puede producirse a través de la interacción de su dominio efector de muerte N-terminal con PROTEÍNAS ADAPTADORAS DE SEÑALIZACIÓN DEL RECEPTOR DE DOMINIOS DE MUERTE. La caspasa 10 interviene en la APOPTOSIS escindiendo y activando CASPASAS EFECTORAS. Existen varias isoformas de esta proteína debido a las múltiples alternativas de corte y empalme del ARN MENSAJERO.
Descriptor Portuguese: Caspase 10
Descriptor French: Caspase 10
Entry term(s): Caspase 10 a
Caspase 10 c
Caspase 10 d
Caspase 10-a
Caspase 10-c
Caspase 10-d
Caspase 10a
Caspase 10c
Caspase 10d
Caspase-10
Mch4 Protease
Protease, Mch4
Tree number(s): D08.811.277.656.262.500.126.550.910
D08.811.277.656.300.200.126.550.910
D12.776.476.075.405.550.910
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053455
Scope note: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. Caspase 10 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Caspase Inhibitors
Registry Number: EC 3.4.22.-
Public MeSH Note: 2007; CASPASE 10 was indexed under CASPASES 1998-2005
History Note: 2007(1998)
Related: Autoimmune Lymphoproliferative Syndrome MeSH
DeCS ID: 52229
Unique ID: D053455
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2015/11/23
Caspase 10 - Preferred
Concept UI M0296687
Scope note A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. Caspase 10 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Preferred term Caspase 10
Entry term(s) Caspase-10
Caspase 10c - Narrower
Concept UI M0303870
Preferred term Caspase 10c
Entry term(s) Caspase 10 c
Caspase 10-c
Caspase 10d - Narrower
Concept UI M0303912
Preferred term Caspase 10d
Entry term(s) Caspase 10 d
Caspase 10-d
Caspase 10a - Narrower
Concept UI M0266009
Preferred term Caspase 10a
Entry term(s) Caspase 10 a
Caspase 10-a
Mch4 Protease
Protease, Mch4



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