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Descriptor English: Caspases, Initiator
Descriptor Spanish: Caspasas Iniciadoras
Descriptor caspasas iniciadoras
Scope note: Subtipo de caspasas que contienen regiones prodominio largas que regulan la activación de la enzima. Las regiones prodominio contienen motivos de interacción proteína-proteína que pueden interactuar con proteínas adaptadoras de señalización específicas como RECEPTORES DEL DOMINIO DE MUERTE, PROTEÍNAS ADAPTADORAS DE SEÑALIZACIÓN CON DOMINIO DED y PROTEÍNAS ADAPTADORAS DE SEÑALIZACIÓN CON DOMINIO CARD. Una vez activadas, las caspasas iniciadoras pueden activar a otras caspasas, como las CASPASAS EFECTORAS.
Descriptor Portuguese: Caspases Iniciadoras
Descriptor French: Caspases initiatrices
Entry term(s): Initiator Caspases
Tree number(s): D08.811.277.656.262.500.126.550
D08.811.277.656.300.200.126.550
D12.776.476.075.405.550
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053471
Scope note: A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Caspase Inhibitors
Registry Number: EC 3.4.22.-
Previous Indexing: Caspases (1999-2006)
Cysteine Proteinases (1997-1998)
Public MeSH Note: 2007
History Note: 2007
DeCS ID: 52225
Unique ID: D053471
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2015/11/23
Caspases, Initiator - Preferred
Concept UI M0491612
Scope note A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.
Preferred term Caspases, Initiator
Entry term(s) Initiator Caspases



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