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Descriptor English: Calcium Channels, L-Type
Descriptor Spanish: Canales de Calcio Tipo L
Descriptor canales del calcio tipo L
Entry term(s) canal de calcio de larga duración
canal de calcio dependiente del voltaje de tipo L
canales de calcio de larga duración
canales de calcio tipo-L
receptores de dihidropiridina
subunidad alfa 1 de VDCC de tipo-L
Scope note: CANALES DE CALCIO dependientes del voltaje de larga duración, presentes en tejidos tanto excitables como no excitables. Son responsables de la contractilidad normal del músculo liso miocárdico y vascular. El canal de tipo L consta de cinco subunidades (alfa-1, alfa-2, beta, gamma y delta). La subunidad alfa-1 es el sitio de unión para los antagonistas del calcio. Los antagonistas del calcio basados en la dihidropiridina se usan como marcadores para estos sitios de unión.
Descriptor Portuguese: Canais de Cálcio Tipo L
Descriptor French: Canaux calciques de type L
Entry term(s): Calcium Channel, L-Type
Calcium Channel, Long-Lasting
Calcium Channels, L Type
Calcium Channels, Long-Lasting
Channel, Long-Lasting Calcium
Dihydropyridine Receptor
Dihydropyridine Receptors
L Type Calcium Channel
L Type Calcium Channels
L Type VDCC
L Type VDCC alpha 1 Subunit
L Type VDCC alpha 2 Subunit
L Type VDCC beta Subunit
L Type VDCC delta Subunit
L Type VDCC gamma Subunit
L Type Voltage Dependent Calcium Channel
L Type Voltage Dependent Calcium Channels
L-Type Calcium Channel
L-Type Calcium Channels
L-Type VDCC
L-Type VDCC alpha-1 Subunit
L-Type VDCC alpha-2 Subunit
L-Type VDCC beta Subunit
L-Type VDCC delta Subunit
L-Type VDCC gamma Subunit
L-Type Voltage-Dependent Calcium Channel
L-Type Voltage-Dependent Calcium Channels
Long Lasting Calcium Channel
Long Lasting Calcium Channels
Long-Lasting Calcium Channel
Long-Lasting Calcium Channels
Receptor, Dihydropyridine
Receptors, Dihydropyridine
VDCC, L-Type
Tree number(s): D12.776.157.530.400.150.400
D12.776.543.550.450.150.400
D12.776.543.585.400.150.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020746
Scope note: Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Calcium Channels (1993-1999)
Muscle Proteins (1993-1999)
Public MeSH Note: 2000; DIHYDROPYRIDINE RECEPTOR (now L-TYPE CALCIUM CHANNELS) was indexed under CALCIUM CHANNELS & MUSCLE PROTEINS 1993-1999
History Note: 2000; use L-TYPE CALCIUM CHANNELS (NM) 1993-1999
Entry Version: VDCC L
DeCS ID: 34475
Unique ID: D020746
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/04
Revision Date: 2020/05/27
Calcium Channels, L-Type - Preferred
Concept UI M0328046
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Preferred term Calcium Channels, L-Type
Entry term(s) Calcium Channel, L-Type
Calcium Channel, Long-Lasting
Calcium Channels, L Type
Calcium Channels, Long-Lasting
Channel, Long-Lasting Calcium
L Type Calcium Channel
L Type Calcium Channels
L Type VDCC
L Type Voltage Dependent Calcium Channel
L Type Voltage Dependent Calcium Channels
L-Type Calcium Channel
L-Type Calcium Channels
L-Type VDCC
L-Type Voltage-Dependent Calcium Channel
L-Type Voltage-Dependent Calcium Channels
Long Lasting Calcium Channel
Long Lasting Calcium Channels
Long-Lasting Calcium Channel
Long-Lasting Calcium Channels
VDCC, L-Type
Receptors, Dihydropyridine - Narrower
Concept UI M0333104
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Preferred term Receptors, Dihydropyridine
Entry term(s) Dihydropyridine Receptor
Dihydropyridine Receptors
L Type VDCC alpha 1 Subunit
L-Type VDCC alpha-1 Subunit
Receptor, Dihydropyridine
L-Type VDCC delta Subunit - Narrower
Concept UI M0333270
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Preferred term L-Type VDCC delta Subunit
Entry term(s) L Type VDCC delta Subunit
L-Type VDCC alpha-2 Subunit - Narrower
Concept UI M0337686
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Preferred term L-Type VDCC alpha-2 Subunit
Entry term(s) L Type VDCC alpha 2 Subunit
L-Type VDCC beta Subunit - Narrower
Concept UI M0333269
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Preferred term L-Type VDCC beta Subunit
Entry term(s) L Type VDCC beta Subunit
L-Type VDCC gamma Subunit - Narrower
Concept UI M0333271
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Scope note Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Preferred term L-Type VDCC gamma Subunit
Entry term(s) L Type VDCC gamma Subunit



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