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Descriptor English: TRPC6 Cation Channel
Descriptor Spanish: Canal Catiónico TRPC6
Descriptor canal catiónico TRPC6
Entry term(s) TRPC6
canal de cationes TRPC6
miembro 6 de la subfamilia C de canales catiónicos de receptores de potencial transitorio
Scope note: Canal catiónico TRPC permeable al calcio, no selectivo, que contiene cuatro REPETICIONES DE ANQUIRINA y es activado por DIACILGLICEROL independientemente de la PROTEÍNA CINASA C. Se expresa en la placenta, pulmón, bazo, ovario e intestino delgado y también en los PODOCITOS de los glomérulos renales. Las mutaciones del gen TRPC6 se asocian a GLOMERULOESCLEROSIS FOCAL Y SEGMENTARIA tipo 2.
Descriptor Portuguese: Canal de Cátion TRPC6
Descriptor French: Membre-6 de la sous-famille C de canaux cationiques à potentiel de récepteur transitoire
Entry term(s): Cation Channel, TRPC6
Channel, TRPC6 Cation
TRPC6
Transient Receptor Potential Cation Channel Subfamily C, Member 6
Tree number(s): D12.776.157.530.400.150.850
D12.776.157.530.400.901.500.500
D12.776.543.550.450.150.900
D12.776.543.585.400.150.850
D12.776.543.585.400.901.500.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000074287
Scope note: A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Calcium Channels (1999-2017)
TRPC Cation Channels (2006-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57077
Unique ID: D000074287
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27
TRPC6 Cation Channel - Preferred
Concept UI M000625933
Scope note A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.
Preferred term TRPC6 Cation Channel
Entry term(s) Cation Channel, TRPC6
Channel, TRPC6 Cation
TRPC6
Transient Receptor Potential Cation Channel Subfamily C, Member 6



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