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Descriptor English: Conotoxins
Descriptor Spanish: Conotoxinas
Descriptor Portuguese: Conotoxinas
Descriptor French: Conotoxines
Entry term(s): Conotoxin
alpha Conotoxin
alpha Conotoxins
alpha-Conotoxin
alpha-Conotoxins
mu Conotoxin
mu Conotoxins
mu-Conotoxin
mu-Conotoxins
Tree number(s): D20.888.590.162
D23.946.580.590.162
D23.946.833.590.162
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020916
Scope note: Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Annotation: OMEGA-CONOTOXINS and OMEGA-CONOTOXIN GVIA are available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Calcium Channel Blockers
Neurotoxins
Previous Indexing: Mollusk Venoms (1986-1999)
Public MeSH Note: 2000
History Note: 2000
DeCS ID: 34514
Unique ID: D020916
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2005/06/30
Conotoxins - Preferred
Concept UI M0328109
Scope note Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Preferred term Conotoxins
Entry term(s) Conotoxin
mu-Conotoxins - Narrower
Concept UI M0333358
Preferred term mu-Conotoxins
Entry term(s) mu Conotoxin
mu Conotoxins
mu-Conotoxin
alpha-Conotoxins - Narrower
Concept UI M0333357
Preferred term alpha-Conotoxins
Entry term(s) alpha Conotoxin
alpha Conotoxins
alpha-Conotoxin



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