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Descriptor English: Conotoxins
Descriptor Spanish: Conotoxinas
Descriptor conotoxinas
Entry term(s) conotoxinas alfa
conotoxinas mu
Scope note: Neurotoxinas peptídicas de caracoles del género CONUS, cazadores de peces marinos. Contienen de 13 a 29 aminoácidos que son muy básicos y forman muchos puentes por medio de enlaces disulfuro. Existen tres tipos de conotoxinas: omega, alfa y mu. Las CONOTOXINAS OMEGA inhiben la entrada de calcio activada por voltaje en la membrana presináptica y, por tanto, la liberación de ACETILCOLINA. Las conotoxinas alfa inhiben el receptor postsináptico de acetilcolina. Las conotoxinas mu impiden que se generen potenciales de acción musculares. (Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Descriptor Portuguese: Conotoxinas
Descriptor French: Conotoxines
Entry term(s): Conotoxin
alpha Conotoxin
alpha Conotoxins
alpha-Conotoxin
alpha-Conotoxins
mu Conotoxin
mu Conotoxins
mu-Conotoxin
mu-Conotoxins
Tree number(s): D20.888.590.162
D23.946.580.590.162
D23.946.833.590.162
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020916
Scope note: Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Annotation: OMEGA-CONOTOXINS and OMEGA-CONOTOXIN GVIA are available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Calcium Channel Blockers
Neurotoxins
Previous Indexing: Mollusk Venoms (1986-1999)
Public MeSH Note: 2000
History Note: 2000
DeCS ID: 34514
Unique ID: D020916
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2005/06/30
Conotoxins - Preferred
Concept UI M0328109
Scope note Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Preferred term Conotoxins
Entry term(s) Conotoxin
mu-Conotoxins - Narrower
Concept UI M0333358
Preferred term mu-Conotoxins
Entry term(s) mu Conotoxin
mu Conotoxins
mu-Conotoxin
alpha-Conotoxins - Narrower
Concept UI M0333357
Preferred term alpha-Conotoxins
Entry term(s) alpha Conotoxin
alpha Conotoxins
alpha-Conotoxin



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