DeCS

Descriptor English:

Conotoxins

Descriptor Spanish:

Conotoxinas

Spanish from Spain

Descriptor	conotoxinas
Entry term(s)	conotoxinas alfa conotoxinas mu
Scope note:	Neurotoxinas peptídicas de caracoles del género CONUS, cazadores de peces marinos. Contienen de 13 a 29 aminoácidos que son muy básicos y forman muchos puentes por medio de enlaces disulfuro. Existen tres tipos de conotoxinas: omega, alfa y mu. Las CONOTOXINAS OMEGA inhiben la entrada de calcio activada por voltaje en la membrana presináptica y, por tanto, la liberación de ACETILCOLINA. Las conotoxinas alfa inhiben el receptor postsináptico de acetilcolina. Las conotoxinas mu impiden que se generen potenciales de acción musculares. (Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

Descriptor Portuguese:

Conotoxinas

Descriptor French:

Conotoxines

Entry term(s):

Conotoxine
Conotoxines-alpha
Conotoxines-mu
Toxines de cône

Tree number(s):

D20.888.590.162
D23.946.580.590.162
D23.946.833.590.162

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D020916

Scope note:

Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

Annotation:

OMEGA-CONOTOXINS and OMEGA-CONOTOXIN GVIA are available

Allowable Qualifiers:

AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Calcium Channel Blockers
Neurotoxins

DeCS ID:

34514

Unique ID:

D020916

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

2000/01/01

Date of Entry:

1999/11/03