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Descriptor English: DNA Helicases
Descriptor Spanish: ADN Helicasas
Descriptor ADN helicasas
Entry term(s) ADN-helicasa
ADN-helicasa dependiente de ATP
ADN-helicasas
ADN-helicasas dependiente de ATP
DNA helicasas
DNA-helicasas
proteína desenrolladora del ADN
proteínas desenrolladoras de ADN
Scope note: Proteínas que promueven el desenrollamiento del ADN bicatenario durante la replicación, uniéndose cooperativamente a regiones monocatenarias del ADN o a regiones cortas de ADN bicatenario sometidas a una apertura transitoria. Además, las ADN-helicasas son ATPasas dependientes del ADN que aprovechan la energía libre de la hidrólisis del ATP para translocar hebras de ADN.
Descriptor Portuguese: DNA Helicases
Descriptor French: Helicase
Entry term(s): ATP Dependent DNA Helicase
ATP Dependent DNA Helicases
ATP-Dependent DNA Helicase
ATP-Dependent DNA Helicases
DNA Helicase
DNA Helicase A
DNA Helicase E
DNA Helicase II
DNA Helicase III
DNA Helicase, ATP-Dependent
DNA Helicases, ATP-Dependent
DNA Unwinding Protein
DNA Unwinding Proteins
Helicase, ATP-Dependent DNA
Helicase, DNA
Helicases, ATP-Dependent DNA
Helicases, DNA
Protein, DNA Unwinding
Unwinding Protein, DNA
Unwinding Proteins, DNA
Tree number(s): D08.811.277.040.025.159
D08.811.399.340
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004265
Scope note: Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Annotation: do not confuse entry term DNA UNWINDING PROTEINS with DNA UNTWISTING PROTEINS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.6.4.-
Previous Indexing: Deoxyribonucleases (1966-1977)
Endonucleases (1973-1977)
Proteins (1966-1977)
specific protein (1966-1977)
Public MeSH Note: 1994; see DNA UNWINDING PROTEINS 1978-1993; for DNA HELICASE A, DNA HELICASE E, DNA HELICASE II were indexed under ADENOSINE TRIPHOSPHATASES & DNA HELICASES 1980-2006; DNA HELICASE III was indexed under DNA HELICASES 1981-2006 & under DNA GYRASE 1980-1981, & under DNA, SUPERHELICAL 1979-1980
History Note: 1994
DeCS ID: 31824
Unique ID: D004265
NLM Classification: QU 137
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1977/04/15
Revision Date: 2020/05/27
DNA Helicases - Preferred
Concept UI M0006674
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Preferred term DNA Helicases
Entry term(s) DNA Helicase
DNA Unwinding Protein
DNA Unwinding Proteins
Helicase, DNA
Helicases, DNA
Protein, DNA Unwinding
Unwinding Protein, DNA
Unwinding Proteins, DNA
DNA Helicase A - Narrower
Concept UI M0083525
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Preferred term DNA Helicase A
DNA Helicase II - Narrower
Concept UI M0083527
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Preferred term DNA Helicase II
DNA Helicase III - Narrower
Concept UI M0077597
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Preferred term DNA Helicase III
ATP-Dependent DNA Helicases - Narrower
Concept UI M0494239
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Preferred term ATP-Dependent DNA Helicases
Entry term(s) ATP Dependent DNA Helicase
ATP Dependent DNA Helicases
ATP-Dependent DNA Helicase
DNA Helicase, ATP-Dependent
DNA Helicases, ATP-Dependent
Helicase, ATP-Dependent DNA
Helicases, ATP-Dependent DNA
DNA Helicase E - Narrower
Concept UI M0083526
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Scope note Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
Preferred term DNA Helicase E



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