| Descriptor English: | Vascular Endothelial Growth Factor Receptor-2 | ||||||
| Descriptor Spanish: |
Receptor 2 de Factores de Crecimiento Endotelial Vascular
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| Descriptor Portuguese: | Receptor 2 de Fatores de Crescimento do Endotélio Vascular | ||||||
| Descriptor French: | Récepteur-2 au facteur croissance endothéliale vasculaire | ||||||
| Entry term(s): |
Fetal Liver Kinase 1 Fetal Liver Kinase-1 Flk 1 Protein Flk 1 Receptor Tyrosine Kinase Flk-1 Protein Flk-1 Receptor Tyrosine Kinase Flk-1, VEGF Receptor KDR Tyrosine Kinase KDR, VEGF Receptor Kinase Insert Domain Receptor Tyrosine Kinase, KDR VEGF Receptor Flk 1 VEGF Receptor Flk-1 VEGF Receptor KDR VEGFR-2 Vascular Endothelial Growth Factor Receptor 2 |
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| Tree number(s): |
D08.811.913.696.620.682.725.400.950.200 D12.776.476.568.400.950.200 D12.776.543.750.630.750.200 D12.776.543.750.750.400.910.200 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D040301 | ||||||
| Scope note: | A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.10.1 | ||||||
| Previous Indexing: |
Protein-Tyrosine Kinase (1993) Receptor Protein-Tyrosine Kinases (1994-2002) Receptors, Growth Factor (1993-2002) |
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| Public MeSH Note: | 2003; VEGFR-2 was indexed under RECEPTORS, PROTEIN-TYROSINE KINASES 1996-2002 |
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| History Note: | 2003; for FETAL LIVER KINASE-1, KDR TYROSINE KINASE, FLK-1 RECEPTOR TYROSINE KINASE & FLK-1 PROTEIN use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR 1993-2002; for VEGFR-2 use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR 1996-2002 |
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| Entry Version: | VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPT 2 |
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| DeCS ID: | 37359 | ||||||
| Unique ID: | D040301 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2003/01/01 | ||||||
| Date of Entry: | 2002/07/03 | ||||||
| Revision Date: | 2016/05/31 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Vascular Endothelial Growth Factor Receptor-2
- Preferred
| Concept UI |
M0185196 |
| Scope note | A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF. |
| Preferred term | Vascular Endothelial Growth Factor Receptor-2 |
| Entry term(s) |
Fetal Liver Kinase 1 Fetal Liver Kinase-1 Flk 1 Protein Flk 1 Receptor Tyrosine Kinase Flk-1 Protein Flk-1 Receptor Tyrosine Kinase Flk-1, VEGF Receptor KDR Tyrosine Kinase KDR, VEGF Receptor Kinase Insert Domain Receptor Tyrosine Kinase, KDR VEGF Receptor Flk 1 VEGF Receptor Flk-1 VEGF Receptor KDR VEGFR-2 Vascular Endothelial Growth Factor Receptor 2 |
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