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Descriptor English: Follistatin
Descriptor Spanish: Folistatina
Descriptor folistatina
Entry term(s) proteína de unión a activinas
proteína fijadora de activinas
Scope note: Proteína ampliamente distribuida que se une directamente a las ACTIVINAS. Funciona como antagonista de activinas, inhibe la secreción de la HORMONA ESTIMULANTE DEL FOLÍCULO, regula la diferenciación celular, y desempeña un importante papel en la embriogénesis. La folistatina es una cadena única polipeptídica glucosilada de aproximadamente 37 kDa y no es miembro de la familia de inhibinas (INHIBINAS). La folistatina se une también a muchos miembros de la familia del FACTOR TRANSFORMADOR DEL CRECIMIENTO BETA y los inhibe.
Descriptor Portuguese: Folistatina
Descriptor French: Follistatine
Entry term(s): Activin Binding Protein
Activin-Binding Protein
Tree number(s): D12.776.157.247
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D038681
Scope note: A broadly distributed protein that binds directly to ACTIVINS. It functions as an activin antagonist, inhibits FOLLICLE STIMULATING HORMONE secretion, regulates CELL DIFFERENTIATION, and plays an important role in embryogenesis. Follistatin is a single glycosylated polypeptide chain of approximately 37-kDa and is not a member of the inhibin family (INHIBINS). Follistatin also binds and neutralizes many members of the TRANSFORMING GROWTH FACTOR BETA family.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Activins (2002)
Glycoproteins (1987-2001)
Inhibins (1987-2001)
Public MeSH Note: 2003; was indexed under FOLLISTATIN (NM) 1988-2002
History Note: 2003; use FOLLISTATIN (NM) 1988-2002
DeCS ID: 37390
Unique ID: D038681
NLM Classification: WK 515
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2004/07/07
Follistatin - Preferred
Concept UI M0157962
Scope note A broadly distributed protein that binds directly to ACTIVINS. It functions as an activin antagonist, inhibits FOLLICLE STIMULATING HORMONE secretion, regulates CELL DIFFERENTIATION, and plays an important role in embryogenesis. Follistatin is a single glycosylated polypeptide chain of approximately 37-kDa and is not a member of the inhibin family (INHIBINS). Follistatin also binds and neutralizes many members of the TRANSFORMING GROWTH FACTOR BETA family.
Preferred term Follistatin
Entry term(s) Activin Binding Protein
Activin-Binding Protein



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