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Descriptor English: Telomeric Repeat Binding Protein 1
Descriptor Spanish: Proteína 1 de Unión a Repeticiones Teloméricas
Descriptor proteína 1 de unión a repeticiones teloméricas
Entry term(s) proteína TRF1
Scope note: Proteína de unión a telómeros, expresada de modo ubico, que se halla presente en los TELÓMEROS en todo el CICLO CELULAR. Es un supresor de la elongación telomérica y puede hallarse implicada en la estabilización de la longitud telomérica. Estructuralmente es diferente a la PROTEÍNA 2 DE UNIÓN A REPETICIONES TELOMÉRICAS por contener residuos de aminoácidos N-terminales de naturaleza ácida.
Descriptor Portuguese: Proteína 1 de Ligação a Repetições Teloméricas
Descriptor French: Protéine-1 se liant aux répétitions télomériques
Entry term(s): PIN2 Protein
TERF1 Protein
TRF1 Protein
TTAGGG Repeat Binding Factor 1
Tree number(s): A11.284.430.106.279.345.190.160.845.500.500
D12.776.260.735.750
D12.776.660.235.700.750
D12.776.664.981.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D035321
Scope note: A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: DNA-Binding Proteins (1997-2002)
Public MeSH Note: 2003; TRF1 PROTEIN was indexed under DNA-BINDING PROTEINS 1997-2002
History Note: 2003; for TRF1 PROTEIN use TELOMERE-BINDING PROTEINS (NM) 1997-2002;
DeCS ID: 37427
Unique ID: D035321
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2005/08/02
Telomeric Repeat Binding Protein 1 - Preferred
Concept UI M0194748
Scope note A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 2 in that it contains acidic N-terminal amino acid residues.
Preferred term Telomeric Repeat Binding Protein 1
Entry term(s) TERF1 Protein
TRF1 Protein
TTAGGG Repeat Binding Factor 1
PIN2 Protein - Related but not broader or narrower
Concept UI M0407292
Scope note An alternatively spliced form of telomeric repeat binding protein 1. In human it lacks 20 amino acids.
Preferred term PIN2 Protein



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