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Descriptor English: Telomeric Repeat Binding Protein 2
Descriptor Spanish: Proteína 2 de Unión a Repeticiones Teloméricas
Descriptor proteína 2 de unión a repeticiones teloméricas
Entry term(s) proteína TRF2
Scope note: Proteína de unión a telómeros, que se expresa de modo ubicuo, y que está presente en los TELÓMEROS en todo el ciclo celular. Es un supresor de la elongación telomérica y puede estar implicada en la estabilización de la longitud telomérica. Es estructuralmente diferente de la PROTEÍNA 1 DE UNIÓN A REPETICIONES TELOMÉRICAS por contener residuos de aminoácidos N-terminales de carácter básico.
Descriptor Portuguese: Proteína 2 de Ligação a Repetições Teloméricas
Descriptor French: Protéine-2 de liaison aux répétitions télomériques
Entry term(s): TERF2 Protein
TRBF2 Protein
TRF2 Protein
Trf2 Gene Product
Tree number(s): A11.284.430.106.279.345.190.160.845.500.750
D12.776.260.735.875
D12.776.660.235.700.875
D12.776.664.981.750
G05.360.160.845.500.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D035341
Scope note: A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the cell cycle. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: DNA-Binding Proteins (1998-2002)
Public MeSH Note: 2003; TRF2 PROTEIN (now TELOMERIC REPEAT BINDING PROTEIN 2) was indexed under DNA-BINDING PROTEINS 1998-2002
History Note: 2003; use TELOMERIC REPEAT BINDING PROTEIN 2 (NM) 1998-2002
DeCS ID: 37428
Unique ID: D035341
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2005/06/30
Telomeric Repeat Binding Protein 2 - Preferred
Concept UI M0282405
Scope note A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the cell cycle. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues.
Preferred term Telomeric Repeat Binding Protein 2
Entry term(s) TERF2 Protein
TRBF2 Protein
TRF2 Protein
Trf2 Gene Product



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