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Descriptor English: alpha-Crystallins
Descriptor Spanish: alfa-Cristalinas
Descriptor alfa-cristalinas
Entry term(s) cristalinas alfa
Scope note: Subclase de cristalinas que proporcionan la mayor parte de la capacidad refractiva y tanslucidez a las lentes (CRISTALINO) en VERTEBRADOS. Las alfa-cristalinas también actúan como caperuzas moleculares que se unen a proteinas desnaturalizadas, dejándolas en solución y manteniendo de ese modo la translucidez de las lentes. Las proteínas se presentan como grandes oligómeros formados a partir de las subunidades de CADENA A DE ALFA-CRISTALINA y CADENA B DE ALFA-CRISTALINA.
Descriptor Portuguese: alfa-Cristalinas
Descriptor French: Cristallines alpha
Entry term(s): Crystallins, alpha
alpha Crystallin
alpha Crystallins
alpha-Crystallin
Tree number(s): D12.776.306.366.100
D12.776.580.157
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D038201
Scope note: A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Crystallins (1965-2002)
Public MeSH Note: 2003; for ALPHA-CRYSTALLIN see CRYSTALLINS 1982-2002
History Note: 2003; for ALPHA-CRYSTALLIN use CRYSTALLINS 1982-2002
DeCS ID: 37439
Unique ID: D038201
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2005/06/30
alpha-Crystallins - Preferred
Concept UI M0005389
Scope note A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits.
Preferred term alpha-Crystallins
Entry term(s) Crystallins, alpha
alpha Crystallin
alpha Crystallins
alpha-Crystallin



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