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Descriptor English: RNA Interference
Descriptor Spanish: Interferencia de ARN
Descriptor interferencia por ARN
Entry term(s) silenciamiento génico postranscripcional
Scope note: Fenómeno de inactivación de un gen en el que ARN BICATENARIOS desencadenan la degradación de ARN MENSAJEROS homólogos. Los ARN bicatenarios específicos son procesados a ARN INTERFERENTE PEQUEÑO (siRNA) que sirve como guía de escisión de ARNm homólogos en el COMPLEJO SILENCIADOR INDUCIDO POR ARN. Durante este proceso también puede desencadenarse la METILACIÓN DEL ADN.
Descriptor Portuguese: Interferência de RNA
Descriptor French: Interférence par ARN
Entry term(s): Co Suppression
Co-Suppression
Cosuppression
Gene Silencing, Post Transcriptional
Gene Silencing, Post-Transcriptional
Gene Silencing, Posttranscriptional
Gene Silencings, Posttranscriptional
Interference, RNA
Post Transcriptional Gene Silencing
Post-Transcriptional Gene Silencing
Post-Transcriptional Gene Silencings
Posttranscriptional Gene Silencing
RNA Silencing
RNAi
Silencing, Post-Transcriptional Gene
Tree number(s): G05.308.203.374.790
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D034622
Scope note: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Allowable Qualifiers: DE drug effects
IM immunology
PH physiology
RE radiation effects
Public MeSH Note: 2003
History Note: 2003
Related: RNA, Small Interfering MeSH
RNA-Induced Silencing Complex MeSH
RNAi Therapeutics MeSH
DeCS ID: 37644
Unique ID: D034622
NLM Classification: QU 58.7
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/06/17
RNA Interference - Preferred
Concept UI M0405879
Scope note A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Preferred term RNA Interference
Entry term(s) Gene Silencing, Post Transcriptional
Gene Silencing, Post-Transcriptional
Gene Silencing, Posttranscriptional
Gene Silencings, Posttranscriptional
Interference, RNA
Post Transcriptional Gene Silencing
Post-Transcriptional Gene Silencing
Post-Transcriptional Gene Silencings
Posttranscriptional Gene Silencing
RNA Silencing
RNAi
Silencing, Post-Transcriptional Gene
Cosuppression - Related but not broader or narrower
Concept UI M0508607
Scope note Joint gene silencing of extra copies of genes, such as TRANSGENES, along with the original endogenous gene. Cosuppression is induced by the presence of the extra gene copies via mechanisms that are related to RNA INTERFERENCE.
Preferred term Cosuppression
Entry term(s) Co Suppression
Co-Suppression



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