| Descriptor English: | RNA-Induced Silencing Complex | ||||||
| Descriptor Spanish: |
Complejo Silenciador Inducido por ARN
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| Descriptor Portuguese: | Complexo de Inativação Induzido por RNA | ||||||
| Descriptor French: | Complexe réprimant l'expression de l'ARN | ||||||
| Entry term(s): |
Complex, RNA-Induced Silencing Multicomponent Nuclease, RISC Nuclease, RISC Multicomponent RISC Multicomponent Nuclease RNA Induced Silencing Complex Silencing Complex, RNA-Induced |
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| Tree number(s): |
D08.811.277.352.355.350.810 D08.811.277.352.700.350.810 D12.776.157.725.500.906 D12.776.664.962.500.906 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D034743 | ||||||
| Scope note: | A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA). |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Endoribonucleases (2001-2002) |
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| Public MeSH Note: | 2003; RNA-INDUCED SILENCING COMPLEX was indexed under RIBONUCLEOPROTEINS 2001-2002 |
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| History Note: | 2003; use RNA-INDUCED SILENCING COMPLEX (NM) 2001-2002 |
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| Entry Version: | RNA IND SILENCING COMPLEX |
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| Related: |
RNA Interference
MeSH RNA, Small Interfering MeSH | ||||||
| DeCS ID: | 37323 | ||||||
| Unique ID: | D034743 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2003/01/01 | ||||||
| Date of Entry: | 2002/07/03 | ||||||
| Revision Date: | 2011/06/24 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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RNA-Induced Silencing Complex
- Preferred
| Concept UI |
M0406104 |
| Scope note | A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA). |
| Preferred term | RNA-Induced Silencing Complex |
| Entry term(s) |
Complex, RNA-Induced Silencing Multicomponent Nuclease, RISC Nuclease, RISC Multicomponent RISC Multicomponent Nuclease RNA Induced Silencing Complex Silencing Complex, RNA-Induced |
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