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Descriptor English: DNA-(Apurinic or Apyrimidinic Site) Lyase
Descriptor Spanish: ADN-(Sitio Apurínico o Apirimidínico) Liasa
Descriptor ADN-(sitio apurínico o apirimidínico) liasa
Entry term(s) ADN-endonucleasa apurínica
ADN-liasa (apurínica o apirimidínica)
ADN-liasa de sítios apurínicos o apirimidínicos
endodesoxirribonucleasa (apurínica o apirimidínica)
liasa AP
Scope note: Enzima de reparación del ADN que cataliza la escisión de residuos ribosa en sitios apurínicos y apirimidínicos del ADN que resultan de la acción de las ADN GLICOSILASAS. La enzima cataliza una reacción de beta-eliminación en la cual se rompe el enlace C-O-P 3' al sitio apurínico o apirimidínico del ADN, dejando un azúcar insaturado 3'-terminal y un producto con un fosfato 5'-terminal. Esta enzima fue clasificada antiguamente como EC 3.1.25.2.
Descriptor Portuguese: DNA Liase (Sítios Apurínicos ou Apirimidínicos)
Descriptor French: DNA-(apurinic or apyrimidinic site) lyase
Entry term(s): AP Endonuclease
AP Lyase
Apurine Apyrimidine Endonuclease
Apurine-Apyrimidine Endonuclease
Apurinic DNA Endonuclease
Apurinic Endonuclease
DNA Endonuclease, Apurinic
DNA Lyase (Apurinic or Apyrimidinic)
Endodeoxyribonuclease (Apurinic or Apyrimidinic)
Endonuclease, AP
Endonuclease, Apurine-Apyrimidine
Endonuclease, Apurinic
Endonuclease, Apurinic DNA
Tree number(s): D08.811.074.750
D08.811.520.241.225
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D043603
Scope note: A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.2.99.18
Previous Indexing: Carbon-Oxygen Lyases (1978-2003)
Public MeSH Note: 2004; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE was indexed under CARBON-OXYGEN LYASES 1996-2003, DEOXYRIBONUCLEASES 1978-1982, ENDODEOXYRIBONUCLEASES 1983-1995, ENDONUCLEASES 1978-1982 & LYASES 1978-1980
History Note: 2004; use DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE (NM) 1980-2003
DeCS ID: 38129
Unique ID: D043603
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2013/07/09
DNA-(Apurinic or Apyrimidinic Site) Lyase - Preferred
Concept UI M0073416
Scope note A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
Preferred term DNA-(Apurinic or Apyrimidinic Site) Lyase
Entry term(s) AP Endonuclease
AP Lyase
Apurine Apyrimidine Endonuclease
Apurine-Apyrimidine Endonuclease
Apurinic DNA Endonuclease
Apurinic Endonuclease
DNA Endonuclease, Apurinic
DNA Lyase (Apurinic or Apyrimidinic)
Endodeoxyribonuclease (Apurinic or Apyrimidinic)
Endonuclease, AP
Endonuclease, Apurine-Apyrimidine
Endonuclease, Apurinic
Endonuclease, Apurinic DNA



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