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Descriptor English: AlkB Enzymes
Descriptor Spanish: Enzimas AlkB
Descriptor enzimas AlkB
Scope note: Familia de dioxigenasas dependientes del ÁCIDO ALFA-CETOGLUTÁRICO y del Fe(II), homólogas a AlkB, enzima que repara los ácidos nucleicos alquilados en la E. coli. Los homólogos de los mamíferos tienen varias especificidades de sustrato y funciones, incluyendo la REPARACIÓN DE ADN, mediante la generación de modificaciones únicas de titubeo (wobble) en la URIDINA del ARNt, la desmetilación de nucleótidos en el ADN y ARN y la desmetilación de los residuos de LISINA en algunas proteínas, incluidas la ACTINA y las histonas (CÓDIGO DE HISTONAS).
Descriptor Portuguese: Enzimas AlkB
Descriptor French: AlkB enzymes
Entry term(s): AlkB Homologs
Alkylated DNA Repair Protein AlkB Homologs
Alkylation Repair Homolog Proteins
Alkylation Repair Homologs
Enzymes, AlkB
Tree number(s): D08.811.074.062
D08.811.682.690.416.139
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071496
Scope note: A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.11.33
Previous Indexing: DNA Repair Enzymes (2004-2016)
Dioxygenases (2004-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56458
Unique ID: D000071496
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/06/28
AlkB Enzymes - Preferred
Concept UI M000614938
Scope note A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).
Preferred term AlkB Enzymes
Entry term(s) AlkB Homologs
Alkylated DNA Repair Protein AlkB Homologs
Alkylation Repair Homolog Proteins
Alkylation Repair Homologs
Enzymes, AlkB



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