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Descriptor English: DNA Glycosylases
Descriptor Spanish: ADN Glicosilasas
Descriptor ADN glicosilasas
Entry term(s) ADN N-glicosidasa
Scope note: Familia de enzimas reparadoras del ADN que reconocen bases nucleotídicas dañadas y las eliminan hidrolizando el enlace N-glicosídico que las une al esqueleto de desoxirribosas de la molécula de ADN. El proceso, denominado REPARACIÓN POR ESCISIÓN DE BASES, puede ser completado por una ADN-(SITIO APURÍNICO O APIRIMIDÍNICO) LIASA, que escinde el azúcar RIBOSA restante del ADN.
Descriptor Portuguese: DNA Glicosilases
Descriptor French: DNA Glycosylases
Entry term(s): DNA Glycosylase
DNA Glycosylase, Methylpurine
DNA N glycosidase
DNA N-glycosidase
Glycosylase, DNA
Glycosylase, Methylpurine DNA
Glycosylases, DNA
Methylpurine DNA Glycosylase
Tree number(s): D08.811.074.249
D08.811.277.450.430.099
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D045647
Scope note: A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the sugar backbone of the DNA molecule. The process called BASE EXCISION REPAIR can be completed by a DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE which excises the remaining RIBOSE sugar from the DNA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.2.2.-
Previous Indexing: DNA (1978-1981)
Glycoside Hydrolases (1978-1981)
N-Glycosyl Hydrolases (1982-2003)
Public MeSH Note: 2004; DNA GLYCOSIDASES was indexed under N-GLYCOSIDE HYDROLASES 1982-2003, under GLYCOSIDE HYDROLASES & DNA 1978-1981
History Note: 2004; use DNA GLYCOSIDASES (NM) 1980-2003
DeCS ID: 38126
Unique ID: D045647
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2006/07/05
DNA Glycosylases - Preferred
Concept UI M0073348
Scope note A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the sugar backbone of the DNA molecule. The process called BASE EXCISION REPAIR can be completed by a DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE which excises the remaining RIBOSE sugar from the DNA.
Preferred term DNA Glycosylases
Entry term(s) DNA Glycosylase
DNA N glycosidase
DNA N-glycosidase
Glycosylase, DNA
Glycosylases, DNA
Methylpurine DNA Glycosylase - Narrower
Concept UI M0073349
Preferred term Methylpurine DNA Glycosylase
Entry term(s) DNA Glycosylase, Methylpurine
Glycosylase, Methylpurine DNA



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