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Descriptor English: Ubiquitin-Protein Ligase Complexes
Descriptor Spanish: Complejos de Ubiquitina-Proteína Ligasa
Descriptor complejos ubicuitina-proteína ligasa
Scope note: Complejos de enzimas que catalizan la unión covalente de la UBICUITINA a otras proteínas formando una unión peptídica entre el C-terminal de GLICINA de la UBICUITINA y grupos alfa-amino de los residuos de LISINA de la proteína. Los complejos desempeñan una función importante en la degradación selectiva de proteínas anormales y de vida corta. El complejo enzimático se puede desagregar en tres componentes lo que implica la activación de la ubicuitina (ENZIMAS ACTIVADORAS DE LA UBICUITINA), conjugación de la ubicuitina al complejo ligasa (ENZIMAS DE CONJUGACIÓN DE LA UBICUITINA), y unión de la ubicuitina al sustrato proteico (UBICUITINA-PROTEÍNA LIGASAS).
Descriptor Portuguese: Complexos Ubiquitina-Proteína Ligase
Descriptor French: Ubiquitin-protein ligase complexes
Entry term(s): Complexes, Ubiquitin-Protein Ligase
Ligase Complexes, Ubiquitin-Protein
Ubiquitin Protein Ligase Complexes
Tree number(s): D08.811.464.938
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D043743
Scope note: Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).
Annotation: UBIQUITIN-PROTEIN LIGASES is also available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.2.23
Previous Indexing: Ligases (1983-2003)
Public MeSH Note: 2004
History Note: 2004
DeCS ID: 38180
Unique ID: D043743
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2016/06/02
Ubiquitin-Protein Ligase Complexes - Preferred
Concept UI M0115796
Scope note Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES).
Preferred term Ubiquitin-Protein Ligase Complexes
Entry term(s) Complexes, Ubiquitin-Protein Ligase
Ligase Complexes, Ubiquitin-Protein
Ubiquitin Protein Ligase Complexes



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