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Descriptor English: Oncolytic Viruses
Descriptor Spanish: Virus Oncolíticos
Descriptor virus oncolíticos
Scope note: VIRUS de replicación competente, selectivos de tumores, con efectos antineoplásicos.Logran esto mediante la producción de proteínas que incrementan la citotoxicidad o provocando una respuesta inmunitaria antitumoral. Son construidos mediante ingeniería genética de tal forma que puedan multiplicarse en las células MALIGNAS pero no en las células normales y se utilizan en VIROTERAPIA ONCOLÍTICA.
Descriptor Portuguese: Vírus Oncolíticos
Descriptor French: Virus oncolytiques
Entry term(s): Oncolytic Virus
Virus, Oncolytic
Viruses, Oncolytic
Tree number(s): B04.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050504
Scope note: Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
Annotation: ONCOGENIC VIRUSES is available
Allowable Qualifiers: CH chemistry
CL classification
DE drug effects
EN enzymology
GD growth & development
GE genetics
IM immunology
IP isolation & purification
ME metabolism
PH physiology
PY pathogenicity
RE radiation effects
UL ultrastructure
Previous Indexing: Viruses (1999-2005)
Public MeSH Note: 2006, 1966-1993; see VIRUSES 1994-2005
History Note: 2006, 1966-1993; use VIRUSES 1994-2005
Related: Oncolytic Virotherapy MeSH
DeCS ID: 50452
Unique ID: D050504
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Oncolytic Viruses - Preferred
Concept UI M0022762
Scope note Tumor-selective, replication competent VIRUSES that have antineoplastic effects. This is achieved by producing cytotoxicity-enhancing proteins and/or eliciting an antitumor immune response. They are genetically engineered so that they can replicate in CANCER cells but not in normal cells, and are used in ONCOLYTIC VIROTHERAPY.
Preferred term Oncolytic Viruses
Entry term(s) Oncolytic Virus
Virus, Oncolytic
Viruses, Oncolytic



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