| Descriptor English: | Cyclin-Dependent Kinase Inhibitor p27 | ||||
| Descriptor Spanish: |
Inhibidor p27 de las Quinasas Dependientes de la Ciclina
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| Descriptor Portuguese: | Inibidor de Quinase Dependente de Ciclina p27 | ||||
| Descriptor French: | Inhibiteur p27 de kinase cycline-dépendante | ||||
| Entry term(s): |
CDK Inhibitor p27 CDK Inhibitor, p27 CDKN1B Protein CDKN4 Protein Cyclin Dependent Kinase Inhibitor 1B Cyclin Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinase Inhibitor 1B Kip1 Protein, p27 p27 CDK Inhibitor p27 Kip1 Protein p27, CDK Inhibitor p27Kip1 Protein |
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| Tree number(s): |
D12.644.360.225.600 D12.776.167.187.600 D12.776.476.225.600 D12.776.624.776.355.600 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D050760 | ||||
| Scope note: | A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Protein Kinase Inhibitors |
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| Registry Number: | 147604-94-2 | ||||
| Public MeSH Note: | 2006; CYCLIN-DEPENDENT KINASE INHIBITOR P27 was indexed under CELL CYCLE PROTEINS & TUMOR SUPPRESSOR PROTEINS 1992-2005 |
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| History Note: | 2006(1992) |
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| DeCS ID: | 50932 | ||||
| Unique ID: | D050760 | ||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
| Date Established: | 2006/01/01 | ||||
| Date of Entry: | 2005/06/30 | ||||
| Revision Date: | 2015/11/23 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Cyclin-Dependent Kinase Inhibitor p27
- Preferred
| Concept UI |
M0203045 |
| Scope note | A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2. |
| Preferred term | Cyclin-Dependent Kinase Inhibitor p27 |
| Entry term(s) |
CDK Inhibitor p27 CDK Inhibitor, p27 CDKN1B Protein CDKN4 Protein Cyclin Dependent Kinase Inhibitor 1B Cyclin Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinase Inhibitor 1B Kip1 Protein, p27 p27 CDK Inhibitor p27 Kip1 Protein p27, CDK Inhibitor p27Kip1 Protein |
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