| Descriptor English: | Cyclin-Dependent Kinase Inhibitor Proteins | ||||||
| Descriptor Spanish: |
Proteínas Inhibidoras de las Quinasas Dependientes de la Ciclina
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| Descriptor Portuguese: | Proteínas Inibidoras de Quinase Dependente de Ciclina | ||||||
| Descriptor French: | Protéines inhibitrices des kinases cyclines-dépendantes | ||||||
| Entry term(s): |
CDKI Proteins CDKI Proteins, CIP-KIP CDKI Proteins, INK4 CIP KIP CDKI Proteins CIP KIP CKI Proteins CIP KIP Cyclin Dependent Kinase Inhibitors CIP-KIP CDKI Proteins CIP-KIP CKI Proteins CIP-KIP Cyclin-Dependent Kinase Inhibitors CKI Proteins CKI Proteins, CIP-KIP CKI Proteins, INK4 Cyclin Dependent Kinase Inhibitor Proteins Cyclin Kinase Inhibitor Proteins Cyclin-Kinase Inhibitor Proteins INK4 CDKI Proteins INK4 CKI Proteins INK4 Cyclin Dependent Kinase Inhibitors INK4 Cyclin-Dependent Kinase Inhibitors Inhibitor Proteins, Cyclin-Kinase Inhibitors of Cyclin Dependent Kinase 4 Proteins Inhibitors of Cyclin-Dependent Kinase 4 Proteins |
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| Tree number(s): |
D12.644.360.225 D12.776.167.187 D12.776.476.225 D12.776.624.776.355 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D050756 | ||||||
| Scope note: | A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Pharm Action: |
Protein Kinase Inhibitors |
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| Public MeSH Note: | 2006 |
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| History Note: | 2006 |
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| DeCS ID: | 50927 | ||||||
| Unique ID: | D050756 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2015/11/23 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Cyclin-Dependent Kinase Inhibitor Proteins
- Preferred
CIP-KIP Cyclin-Dependent Kinase Inhibitors
- Narrower
INK4 Cyclin-Dependent Kinase Inhibitors
- Narrower
| Concept UI |
M0477620 |
| Scope note | A group of cell cycle proteins that negatively regulate the activity of CYCLIN/CYCLIN-DEPENDENT KINASE complexes. They inhibit CELL CYCLE progression and help control CELL PROLIFERATION following GENOTOXIC STRESS as well as during CELL DIFFERENTIATION. |
| Preferred term | Cyclin-Dependent Kinase Inhibitor Proteins |
| Entry term(s) |
CDKI Proteins CKI Proteins Cyclin Dependent Kinase Inhibitor Proteins Cyclin Kinase Inhibitor Proteins Cyclin-Kinase Inhibitor Proteins Inhibitor Proteins, Cyclin-Kinase |
| Concept UI |
M0477621 |
| Preferred term | CIP-KIP Cyclin-Dependent Kinase Inhibitors |
| Entry term(s) |
CDKI Proteins, CIP-KIP CIP KIP CDKI Proteins CIP KIP CKI Proteins CIP KIP Cyclin Dependent Kinase Inhibitors CIP-KIP CDKI Proteins CIP-KIP CKI Proteins CKI Proteins, CIP-KIP |
| Concept UI |
M0477631 |
| Scope note | A family of cell cycle proteins containing ANKYRIN REPEATS that are specific inhibitors of cyclin D-dependent kinases. INK4 proteins bind to CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. They dissociate cyclin-CDK complexes and regulate a CELL CYCLE checkpoint in early G1 PHASE. |
| Preferred term | INK4 Cyclin-Dependent Kinase Inhibitors |
| Entry term(s) |
CDKI Proteins, INK4 CKI Proteins, INK4 INK4 CDKI Proteins INK4 CKI Proteins INK4 Cyclin Dependent Kinase Inhibitors Inhibitors of Cyclin Dependent Kinase 4 Proteins Inhibitors of Cyclin-Dependent Kinase 4 Proteins |
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