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Descriptor English: Cyclin-Dependent Kinase Inhibitor p15
Descriptor Spanish: Inhibidor p15 de las Quinasas Dependientes de la Ciclina
Descriptor inhibidor p15 de cinasas dependientes de ciclinas
Scope note: Inhibidor INK4 de las cinasas dependientes de ciclina que contiene cuatro REPETICIONES DE TIPO ANQUIRINA. Con frecuencia INK4B está inactivada por deleciones, mutaciones o hipermetilación en las NEOPLASIAS HEMATOLÓGICAS.
Descriptor Portuguese: Inibidor de Quinase Dependente de Ciclina p15
Descriptor French: Inhibiteur p15 de kinase cycline-dépendante
Entry term(s): CDK4 Inhibitor, p15
CDKN2B Protein
Cyclin Dependent Kinase Inhibitor 2B
Cyclin Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor 2B
INK4B Protein
INK4b Cyclin Dependent Kinase Inhibitor
INK4b Cyclin-Dependent Kinase Inhibitor
p15 CDK4 Inhibitor
p15INK4B Protein
Tree number(s): D12.644.360.225.100
D12.776.167.187.100
D12.776.476.225.100
D12.776.624.776.355.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050762
Scope note: An INK4 cyclin-dependent kinase inhibitor containing four ANKYRIN-LIKE REPEATS. INK4B is often inactivated by deletions, mutations, or hypermethylation in HEMATOLOGIC NEOPLASMS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Protein Kinase Inhibitors
Public MeSH Note: 2006; CYCLIN-DEPENDENT KINASE INHIBITOR P15 was indexed under TUMOR SUPPRESSOR PROTEINS & CELL CYCLE PROTEINS 2004-2005, under PROTEIN P16 2002-2004, & under CARRIER PROTEINS 1994-2001
History Note: 2006(1994)
DeCS ID: 50928
Unique ID: D050762
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2015/11/23
Cyclin-Dependent Kinase Inhibitor p15 - Preferred
Concept UI M0236014
Scope note An INK4 cyclin-dependent kinase inhibitor containing four ANKYRIN-LIKE REPEATS. INK4B is often inactivated by deletions, mutations, or hypermethylation in HEMATOLOGIC NEOPLASMS.
Preferred term Cyclin-Dependent Kinase Inhibitor p15
Entry term(s) CDK4 Inhibitor, p15
CDKN2B Protein
Cyclin Dependent Kinase Inhibitor 2B
Cyclin Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor 2B
INK4B Protein
INK4b Cyclin Dependent Kinase Inhibitor
INK4b Cyclin-Dependent Kinase Inhibitor
p15 CDK4 Inhibitor
p15INK4B Protein



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