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Descriptor English: Cyclin-Dependent Kinase Inhibitor p21
Descriptor Spanish: Inhibidor p21 de las Quinasas Dependientes de la Ciclina
Descriptor Portuguese: Inibidor de Quinase Dependente de Ciclina p21
Descriptor French: Inhibiteur p21 de kinase cycline-dépendante
Entry term(s): CDK2 Associated Protein 20 kDa
CDK2-Associated Protein 20 kDa
CDKN1 Protein
CDKN1A Protein
Cdk Interacting Protein 1
Cdk-Interacting Protein 1
Cdk2 Inhibitor Protein
Cell Cycle Regulator p21
Cyclin Dependent Kinase Inhibitor 1A Protein
Cyclin Dependent Kinase Inhibitor p21
Cyclin Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor 1A Protein
Senescent Cell Derived Inhibitor Protein 1
Senescent Cell-Derived Inhibitor Protein 1
p21 Cell Cycle Regulator
p21 Cyclin Kinase Inhibitor
Tree number(s): D12.644.360.225.500
D12.776.157.687.250
D12.776.167.187.500
D12.776.476.225.500
D12.776.624.776.355.500
D12.776.660.720.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050759
Scope note: A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN-DEPENDENT KINASES and associates with PROLIFERATING CELL NUCLEAR ANTIGEN and CASPASE 3.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Protein Kinase Inhibitors
Public MeSH Note: 2006; CYCLIN-DEPENDENT KINASE INHIBITOR P21 was indexed under CYCLINS 1993-2005, & under CELL CYCLE PROTEINS 2005
History Note: 2006(1993)
DeCS ID: 50931
Unique ID: D050759
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2017/05/24
Cyclin-Dependent Kinase Inhibitor p21 - Preferred
Concept UI M0224308
Scope note A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN-DEPENDENT KINASES and associates with PROLIFERATING CELL NUCLEAR ANTIGEN and CASPASE 3.
Preferred term Cyclin-Dependent Kinase Inhibitor p21
Entry term(s) CDK2 Associated Protein 20 kDa
CDK2-Associated Protein 20 kDa
CDKN1 Protein
CDKN1A Protein
Cdk Interacting Protein 1
Cdk-Interacting Protein 1
Cdk2 Inhibitor Protein
Cell Cycle Regulator p21
Cyclin Dependent Kinase Inhibitor 1A Protein
Cyclin Dependent Kinase Inhibitor p21
Cyclin Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor 1A Protein
Senescent Cell Derived Inhibitor Protein 1
Senescent Cell-Derived Inhibitor Protein 1
p21 Cell Cycle Regulator
p21 Cyclin Kinase Inhibitor



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