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Descriptor English: Metabolic Detoxication, Phase I
Descriptor Spanish: Fase I de la Desintoxicación Metabólica
Descriptor fase I de la desintoxicación metabólica
Entry term(s) fase I de desintoxicación
Scope note: Tratamiento de sustancias exógenas para prepararlas para la conjugación en la FASE II DE DESINTOXICACIÓN. Entre las enzimas de la fase I se encuentran las enzimas del CITOCROMO P450 y algunas OXIDORREDUCTASAS. El exceso de inducción de la fase I sobre la fase II de desintoxicación incrementa las concentraciones de RADICALES LIBRES, que pueden inducir CÁNCER y otros daños celulares. La inducción o el antagonismo de la fase I de desintoxicación constituye la base de algunas INTERACCIONES DE MEDICAMENTOS.
Descriptor Portuguese: Desintoxicação Metabólica Fase I
Descriptor French: Détoxication de phase I
Entry term(s): Detoxication, Oxidative Metabolic
Detoxications, Oxidative Metabolic
Detoxification, Phase I
Detoxifications, Phase I
Metabolic Detoxication, Oxidative
Metabolic Detoxications, Oxidative
Metabolic Detoxification, Phase I
Oxidative Metabolic Detoxication
Oxidative Metabolic Detoxications
Phase I Detoxification
Tree number(s): G03.171.450.500
G03.787.225.450.500
G07.690.725.225.450.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050216
Scope note: Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
Allowable Qualifiers: EH ethnology
GE genetics
IM immunology
PH physiology
RE radiation effects
Public MeSH Note: 2006
History Note: 2006
Entry Version: METAB DETOX PHASE I
Related: Drug Interactions MeSH
DeCS ID: 51246
Unique ID: D050216
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/06/30
Metabolic Detoxication, Phase I - Preferred
Concept UI M0473292
Scope note Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
Preferred term Metabolic Detoxication, Phase I
Entry term(s) Detoxication, Oxidative Metabolic
Detoxications, Oxidative Metabolic
Detoxification, Phase I
Detoxifications, Phase I
Metabolic Detoxication, Oxidative
Metabolic Detoxications, Oxidative
Metabolic Detoxification, Phase I
Oxidative Metabolic Detoxication
Oxidative Metabolic Detoxications
Phase I Detoxification



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