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Descriptor English: Metabolic Detoxication, Phase II
Descriptor Spanish: Fase II de la Desintoxicación Metabólica
Descriptor fase II de la desintoxicación metabólica
Entry term(s) fase II de desintoxicación
Scope note: Conjugación de sustancias exógenas con diversos sustituyentes hidrofílicos para formar productos hidrosolubles que sean excretables por la ORINA. Las modificaciones de la fase II incluyen la ACILACIÓN, la AMINACIÓN y la conjugación del GLUTATIÓN. Entre las enzimas de la fase II se encuentran: la GLUTATIÓN-TRANSFERASA y la GLUCURONOSIL-TRANSFERASA. En cierto sentido estas reacciones desintoxican los productos de reacción de la fase I.
Descriptor Portuguese: Desintoxicação Metabólica Fase II
Descriptor French: Détoxication de phase II
Entry term(s): Conjugative Metabolic Detoxication
Conjugative Metabolic Detoxications
Detoxication, Conjugative Metabolic
Detoxications, Conjugative Metabolic
Detoxification, Phase II
Detoxifications, Phase II
Metabolic Detoxication, Conjugative
Metabolic Detoxications, Conjugative
Metabolic Detoxification, Phase II
Phase II Detoxification
Phase II Detoxifications
Tree number(s): G03.171.450.750
G03.787.225.450.750
G07.690.725.225.450.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050217
Scope note: The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.
Allowable Qualifiers: EH ethnology
GE genetics
IM immunology
PH physiology
RE radiation effects
Public MeSH Note: 2006
History Note: 2006
Entry Version: METAB DETOX PHASE II
Related: Antioxidant Response Elements MeSH
Protein Processing, Post-Translational MeSH
DeCS ID: 51247
Unique ID: D050217
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/06/30
Metabolic Detoxication, Phase II - Preferred
Concept UI M0473296
Scope note The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.
Preferred term Metabolic Detoxication, Phase II
Entry term(s) Conjugative Metabolic Detoxication
Conjugative Metabolic Detoxications
Detoxication, Conjugative Metabolic
Detoxications, Conjugative Metabolic
Detoxification, Phase II
Detoxifications, Phase II
Metabolic Detoxication, Conjugative
Metabolic Detoxications, Conjugative
Metabolic Detoxification, Phase II
Phase II Detoxification
Phase II Detoxifications



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