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Descriptor English: Transforming Growth Factor beta1
Descriptor Spanish: Factor de Crecimiento Transformador beta1
Descriptor factor de crecimiento transformador beta1
Entry term(s) TGF-beta1
factor beta1 del crecimiento transformador
factor de crecimiento transformante beta-1
factor del crecimiento transformador beta1
Scope note: Subtipo de factor de crecimiento transformante beta que es sintetizado por una amplia variedad de células. Se sintetiza como molécula precursora que es desdoblada para formar el TGF-beta 1 maduro y el péptido asociado a latencia TGF-beta 1. La asociación de los productos de desdoblamiento da lugar a la formación de una proteína latente que debe ser activada para unirse a su receptor. Los defectos en el gen que codifica el TGF-beta 1 son la causa del SÍNDROME DE CAMURATI-ENGELMANN.
Descriptor Portuguese: Fator de Crescimento Transformador beta1
Descriptor French: Facteur de croissance transformant bêta-1
Entry term(s): Latency-Associated Protein, TGF-beta1
TGF beta 1
TGF beta1 Latency Associated Protein
TGF beta1LAP
TGF-beta-1
TGF-beta1
TGF-beta1 Latency-Associated Protein
TGF-beta1LAP
Transforming Growth Factor beta 1 Latency Associated Peptide
Transforming Growth Factor beta I
Transforming Growth Factor-beta1
Tree number(s): D12.644.276.374.687.100
D12.644.276.954.775.100
D12.776.467.374.687.100
D12.776.467.942.775.100
D23.529.374.687.100
D23.529.942.775.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053773
Scope note: A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Camurati-Engelmann Syndrome
Public MeSH Note: 2007; TRANSFORMING GROWTH FACTOR BETA1 was indexed under TRANSFORMING GROWTH FACTOR 2000-2006; TRANSFORMING GROWTH FACTOR BETA 1 LATENCY ASSOCIATED PEPTIDE was indexed under TRANSFORMING GROWTH FACTOR 1992-2006; TRANSFORMING GROWTH FACTOR BETA I was indexed under PROTEINS 2005-2006
History Note: 2007(1992)
DeCS ID: 52285
Unique ID: D053773
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2020/02/21
Transforming Growth Factor beta1 - Preferred
Concept UI M0024760
Scope note A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Preferred term Transforming Growth Factor beta1
Entry term(s) TGF beta 1
TGF-beta-1
TGF-beta1
Transforming Growth Factor beta I
Transforming Growth Factor-beta1
Transforming Growth Factor beta 1 Latency Associated Peptide - Narrower
Concept UI M0202415
Preferred term Transforming Growth Factor beta 1 Latency Associated Peptide
Entry term(s) Latency-Associated Protein, TGF-beta1
TGF beta1 Latency Associated Protein
TGF beta1LAP
TGF-beta1 Latency-Associated Protein
TGF-beta1LAP



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