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Descriptor English: HIV Reverse Transcriptase
Descriptor Spanish: Transcriptasa Inversa del VIH
Descriptor transcriptasa inversa del VIH
Scope note: Transcriptasa inversa codificada por el GEN POL del VIH. Es un heterodímero de subunidades de 66 kDa y 51 kDa que derivan de una proteína precursora común. El heterodímero tiene también actividad RNAsa H (RIBONUCLEASA H DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA) que desempeña un papel esenial en el proceso de replicación viral.
Descriptor Portuguese: Transcriptase Reversa do HIV
Descriptor French: Transcriptase inverse du VIH
Entry term(s): Reverse Transcriptase, HIV
Reverse Transcriptase, Human Immunodeficiency Virus
Transcriptase, HIV Reverse
Tree number(s): D08.811.913.696.445.308.300.750.187
D12.776.964.775.375.545.875
D12.776.964.775.375.750.187
D12.776.964.775.562.764.875
D12.776.964.900.750.500.545.875
D12.776.964.900.750.500.750.187
D12.776.964.970.600.850.375.545.875
D12.776.964.970.600.850.375.750.187
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054303
Scope note: A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.7.49
Previous Indexing: RNA-Directed DNA Polymerase (1983-2007)
Public MeSH Note: 2008
History Note: 2008
DeCS ID: 52726
Unique ID: D054303
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2013/07/08
HIV Reverse Transcriptase - Preferred
Concept UI M0503898
Scope note A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process.
Preferred term HIV Reverse Transcriptase
Entry term(s) Reverse Transcriptase, HIV
Reverse Transcriptase, Human Immunodeficiency Virus
Transcriptase, HIV Reverse



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